Cozzi R, Bona R, Polani S, De Salvia R
Dipartimento di Genetica e Biologia Molecolare, Università La Sapienza, Roma, Italy.
Mutagenesis. 1990 Jul;5(4):397-401. doi: 10.1093/mutage/5.4.397.
Recently, retinoids have been studied for their ability to modify the carcinogenic/mutagenic activity of chemical compounds. Results show that they can inhibit the malignant transformation of cells, the induction of cancer in experimental animals and the mutagenicity of promutagens. Our experiments examine how retinol and retinoic acid can decrease the frequency of sister chromatid exchange (SCE) induced by two indirect mutagens/carcinogens (cyclophosphamide and 7,12-dimethylbenz[a]anthracene) in an epithelial liver cell line of male Chinese hamster (CHEL cells). These cells are metabolically competent and activate different classes of promutagens into biologically active metabolites. Our results are consistent with the suggestion that retinoids modulate the genotoxicity of indirect-acting mutagens by altering their metabolic activation or cellular detoxification processes or both.
最近，人们对类视黄醇改变化合物致癌/致突变活性的能力进行了研究。结果表明，它们可以抑制细胞的恶性转化、实验动物中的癌症诱导以及前诱变剂的致突变性。我们的实验研究了视黄醇和视黄酸如何降低由两种间接诱变剂/致癌物（环磷酰胺和7,12-二甲基苯并[a]蒽）在雄性中国仓鼠的上皮肝细胞系（CHEL细胞）中诱导的姐妹染色单体交换（SCE）频率。这些细胞具有代谢活性，能将不同种类的前诱变剂激活为生物活性代谢物。我们的结果与以下观点一致，即类视黄醇通过改变间接作用诱变剂的代谢激活或细胞解毒过程或两者来调节其遗传毒性。
