Nagaveni N B, Praveen Reddy B, Umashankar K V, Pranav B, Sreedevi Reddy, Radhika N B
Department of Pedodontics and Preventive Dentistry, College of Dental Sciences, Davangere, Karnataka, India.
J Clin Pediatr Dent. 2010 Fall;35(1):81-7. doi: 10.17796/jcpd.35.1.q69168v5268234k9.
Platelet-rich-plasma (PRP) is a type of natural source of autologous growth factors, and has been used successfully in various fields. However the use ofPRP in children is not well documented.
To evaluate the efficacy of adding PRP to a bone graft in the bone regeneration of cystic bony defects following cystectomy.
Study sample included 20 children who were randomly divided into two groups with 10 patients in each group; all underwent cystectomy In the first group (test group), after cystectomy the cystic defect was filled with PRP and bone graft. In the second group (control group) bone graft alone (without PRP) was used. Radiographs were recorded at 1 month, 2 months, 4 months and 6 months intervals after surgery to evaluate the defect bone fill in both groups.
The post-operative successive radiographs in the test group showed a significantly greater regeneration of bone in the height of bony defects with application of PRP to bone graft as compared to the control group. In the test group, by the first post operative month, about 58% of the defect was filled, which gradually increased in each month and showed about 94% of defect-fill by 6 months. In the control group, similar observation revealed only 31% of defect-fill by the first post-operative month and a 47% defect-fill at 6 months.
The addition of PRP to bone graft appeared to enhance bone regeneration considerably. The combination of PRP and bone graft might have a potential for routine clinical use for regeneration of cystic bony defects in children.
富血小板血浆（PRP）是一种自体生长因子的天然来源，已成功应用于各个领域。然而，PRP在儿童中的应用尚无充分文献记载。
评估在囊肿切除术后囊性骨缺损的骨再生中，将PRP添加到骨移植中的疗效。
研究样本包括20名儿童，随机分为两组，每组10例；所有患儿均接受囊肿切除术。第一组（试验组）在囊肿切除术后，用PRP和骨移植填充囊性缺损。第二组（对照组）仅使用骨移植（不含PRP）。术后分别于1个月、2个月、4个月和6个月进行X线片检查，以评估两组缺损骨的填充情况。
试验组术后连续的X线片显示，与对照组相比，在骨移植中应用PRP后，骨缺损高度的骨再生明显更多。试验组术后第一个月，约58%的缺损被填充，此后每月逐渐增加，6个月时显示约94%的缺损被填充。对照组的类似观察显示，术后第一个月仅31%的缺损被填充，6个月时为47%。
在骨移植中添加PRP似乎能显著促进骨再生。PRP与骨移植的联合应用可能有潜力用于儿童囊性骨缺损再生的常规临床应用。
