Al-Hamed Faez Saleh, Mahri Mohammed, Al-Waeli Haider, Torres Jesus, Badran Zahi, Tamimi Faleh
Faculty of Dentistry, McGill University, Montreal, QC, Canada.
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Jazan University, Jazan, Saudi Arabia.
Front Cardiovasc Med. 2019 Sep 3;6:126. doi: 10.3389/fcvm.2019.00126. eCollection 2019.
Platelet concentrates (PCs) are biological autologous products derived from the patient's whole blood and consist mainly of supraphysiologic concentration of platelets and growth factors (GFs). These GFs have anti-inflammatory and healing enhancing properties. Overall, PCs seem to enhance bone and soft tissue healing in alveolar ridge augmentation, periodontal surgery, socket preservation, implant surgery, endodontic regeneration, sinus augmentation, bisphosphonate related osteonecrosis of the jaw (BRONJ), osteoradionecrosis, closure of oroantral communication (OAC), and oral ulcers. On the other hand, no effect was reported for gingival recession and guided tissue regeneration (GTR) procedures. Also, PCs could reduce pain and inflammatory complications in temporomandibular disorders (TMDs), oral ulcers, and extraction sockets. However, these effects have been clinically inconsistent across the literature. Differences in study designs and types of PCs used with variable concentration of platelets, GFs, and leucocytes, as well as different application forms and techniques could explain these contradictory results. This study aims to review the clinical applications of PCs in oral and craniofacial tissue regeneration and the role of their molecular components in tissue healing.
血小板浓缩物（PCs）是源自患者全血的生物自体产品，主要由超生理浓度的血小板和生长因子（GFs）组成。这些生长因子具有抗炎和促进愈合的特性。总体而言，血小板浓缩物似乎能促进牙槽嵴增高、牙周手术、拔牙窝保存、种植手术、牙髓再生、鼻窦增高、双膦酸盐相关颌骨坏死（BRONJ）、放射性骨坏死、口腔上颌窦瘘（OAC）闭合及口腔溃疡等方面的骨和软组织愈合。另一方面，未报道其对牙龈退缩和引导组织再生（GTR）手术有效果。此外，血小板浓缩物可减轻颞下颌关节紊乱病（TMDs）、口腔溃疡和拔牙窝的疼痛及炎症并发症。然而，这些效果在整个文献中临床结果并不一致。研究设计的差异、所使用的血小板浓缩物类型（其血小板、生长因子和白细胞浓度不同），以及不同的应用形式和技术，可能解释了这些相互矛盾的结果。本研究旨在综述血小板浓缩物在口腔和颅面组织再生中的临床应用及其分子成分在组织愈合中的作用。
