Department of Pharmacology, Mahatma Gandhi Medical College, Sitapura, Jaipur 302 022, India.
Indian J Pharmacol. 2010 Dec;42(6):354-7. doi: 10.4103/0253-7613.71913.
To compare the analgesic activity of nimesulide and paracetamol alone and their combination in animal models for the degree of analgesia and the time course of action.
Analgesia was studied in albino rats using formalin test and in albino mice using writhing test and the radiant heat method. For each test, four groups of six animals each were orally fed with a single dose of nimesulide, paracetamol, and combination of nimesulide + paracetamol and gum acacia as control, respectively.
In all the three test models, all three drug treatments showed significant analgesia (P < 0.001) as compared to control, but there was no significant difference in the analgesia produced by either drugs alone or in combination. The radiant heat method demonstrated a quicker onset and longer duration of action with nimesulide, whereas writhing test showed a quicker onset of action with paracetamol. In formalin test, greater degree of analgesia was seen with individual drugs than that of the combination, though this difference was not statistically significant.
Nimesulide and paracetamol combination offers no advantage over nimesulide alone or paracetamol alone, either in terms of degree of analgesia or onset of action. Therefore, our study supports the reports claiming irrationality of the fixed dose combination of nimesulide and paracetamol.
比较单独使用尼美舒利和对乙酰氨基酚以及它们的联合使用在动物模型中的镇痛活性，评估其镇痛程度和作用时间。
使用福尔马林试验研究了白化大鼠的镇痛作用，使用扭体试验和辐射热法研究了白化小鼠的镇痛作用。对于每种试验，每组 6 只动物分别口服给予单剂量的尼美舒利、对乙酰氨基酚、尼美舒利+对乙酰氨基酚联合用药和阿拉伯胶作为对照。
在所有三种试验模型中，与对照组相比，三种药物治疗均显示出显著的镇痛作用（P<0.001），但单独使用或联合使用药物产生的镇痛作用没有显著差异。辐射热法显示尼美舒利起效更快，作用持续时间更长，而扭体试验显示对乙酰氨基酚起效更快。在福尔马林试验中，与单独使用药物相比，联合用药的镇痛效果稍好，但差异无统计学意义。
尼美舒利和对乙酰氨基酚联合用药在镇痛程度或作用时间方面没有优于单独使用尼美舒利或对乙酰氨基酚，因此，我们的研究支持了有关尼美舒利和对乙酰氨基酚固定剂量联合使用不合理的报告。
