Department of Zoology, Unit of Endocrinology, Bharathiar Univeristy, Coimbatore - 641 046, India.
Indian J Pharmacol. 2010 Dec;42(6):388-91. doi: 10.4103/0253-7613.71923.
This study was designed to investigate the effect of Phyllanthus reticulatus on lipid profile and oxidative stress in hypercholesterolemic albino rats.
Hypercholesterolemia was induced in albino rats by administration of atherogenic diet for 2 weeks. Experimental rats were divided into different groups: normal, hypercholesterolemic control and P. reticulatus treated (250 and 500 mg/kg body weight doses for 45 days). After the treatment period of 45(th) day triglyceride, VLDL-cholesterol, HDL-cholesterol, total cholesterol (TC), LDL-cholesterol and oxidative stress (protein carbonyl) were assayed and compared with hypercholesterolemic control.
The aqueous extract of P. reticulatus (250 mg and 500 mg/kg) produced significant reduction (P < 0.05) in triglyceride, VLDL-cholesterol, total cholesterol (TC), LDL-cholesterol and oxidative stress (protein carbonyl) while increased HDL-cholesterol in atherogenic diet-induced hypercholesterolemic rats at the end of the treatment period (45 days). However, the reduction in the above parameters was comparable with hypercholesterolemic control. Thus, aqueous extract of P. reticulatus is effective in controlling TC, lipid profile and oxidative stress in hypercholesterolemic animals.
The results suggest the aqueous extract of P. reticulatus can be utilized for prevention of atherosclerosis in hypercholesterolemic patients.
本研究旨在探讨叶下珠对高胆固醇血症白化大鼠血脂谱和氧化应激的影响。
通过给予致动脉粥样硬化饮食 2 周诱导白化大鼠产生高胆固醇血症。实验大鼠分为正常组、高胆固醇血症对照组和叶下珠治疗组（250 和 500mg/kg 体重剂量，共 45 天）。在第 45 天的治疗期结束后，测定甘油三酯、VLDL-胆固醇、HDL-胆固醇、总胆固醇（TC）、LDL-胆固醇和氧化应激（蛋白质羰基），并与高胆固醇血症对照组进行比较。
叶下珠水提物（250mg 和 500mg/kg）在治疗期结束时（45 天）可显著降低（P<0.05）致动脉粥样硬化饮食诱导的高胆固醇血症大鼠的甘油三酯、VLDL-胆固醇、总胆固醇（TC）、LDL-胆固醇和氧化应激（蛋白质羰基），同时增加 HDL-胆固醇。然而，上述参数的降低与高胆固醇血症对照组相当。因此，叶下珠水提物可有效控制高胆固醇血症动物的 TC、血脂谱和氧化应激。
结果表明，叶下珠水提物可用于预防高胆固醇血症患者的动脉粥样硬化。
