布氏厚皮树乙醇提取物对大鼠的抗高胆固醇活性。
Antihypercholesterolemic activity of ethanolic extract of Buchholzia coriacea in rats.
作者信息
Olaiya C O, Omolekan T O
机构信息
Department of Biochemistry, University of Ibadan, Ibadan, Nigeria.
出版信息
Afr Health Sci. 2013 Dec;13(4):1084-90. doi: 10.4314/ahs.v13i4.32.
BACKGROUND
Hypercholesterolemia is a condition characterised with high level of cholesterol in the blood.
OBJECTIVES
The effect of ethanolic extract of Buchholzia coriacea (EEBC) on the lipid profile levels and extent of lipid peroxidation in hypercholesterolemic albino rats was investigated in this study.
METHODS
Thirty albino rats were divided into six different groups which consist of group 1 (control), group 2 (hypercholesterolemic rats), group 3 (hypercholesterolemic rats treated with ethanolic extract of EEBC), group 4 (hypercholesterolemic rats treated with questran), group 5 (normal rats treated with EEBC) and group 6 (normal rats treated with questran). The rats were sacrificed at the end of the sixth week and assay conducted for Aspartate Transaminase (AST), Alanine Transaminase (ALT), lipid profile and biomarker of oxidative stress.
RESULTS
The serum and liver total cholesterol and LDL - cholesterol levels as well as lipid peroxidation in the EEBC-treated hypercholesterolemic rats were significantly reduced (p < 0.05) when compared with the untreated hypercholesterolemic rats. The activities of AST and ALT in EEBC - treated hypercholesterolemic rats were not significantly different (p > 0.05) from the control.
CONCLUSIONS
The results suggest that Buchholzia coriacea seeds contain potent antihypercholesterolemic agent which may find clinical application in ameliorating hypercholesterolemia and its attendant complications.
背景
高胆固醇血症是一种血液中胆固醇水平升高的病症。
目的
本研究调查了厚皮布氏豆乙醇提取物（EEBC）对高胆固醇血症白化大鼠脂质谱水平和脂质过氧化程度的影响。
方法
将30只白化大鼠分为六个不同组，包括第1组（对照组）、第2组（高胆固醇血症大鼠组）、第3组（用EEBC乙醇提取物治疗的高胆固醇血症大鼠组）、第4组（用消胆胺治疗的高胆固醇血症大鼠组）、第5组（用EEBC治疗的正常大鼠组）和第6组（用消胆胺治疗的正常大鼠组）。在第六周结束时处死大鼠，并进行天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）、脂质谱和氧化应激生物标志物的检测。
结果
与未治疗的高胆固醇血症大鼠相比，用EEBC治疗的高胆固醇血症大鼠的血清和肝脏总胆固醇及低密度脂蛋白胆固醇水平以及脂质过氧化显著降低（p<0.05）。用EEBC治疗的高胆固醇血症大鼠的AST和ALT活性与对照组无显著差异（p>0.05）。
结论
结果表明，厚皮布氏豆种子含有有效的抗高胆固醇血症药物，可能在改善高胆固醇血症及其相关并发症方面有临床应用价值。
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