艰难梭菌 PS-II 细胞壁多糖重复单元的首次合成。

First synthesis of C. difficile PS-II cell wall polysaccharide repeating unit.

机构信息

Novartis Vaccines & Diagnostics, Vaccine Chemistry Department, Via Fiorentina 1, 53100 Siena, Italy.

出版信息

Org Lett. 2011 Feb 4;13(3):378-81. doi: 10.1021/ol1026188. Epub 2010 Dec 29.

PMID:21190352

Abstract

Clostridium difficile is the most commonly diagnosed cause of nosocomial diarrhea with increasing incidence and mortality among elderly and hospitalized patients. We report the first synthesis of the surface polysaccharide PS-II repeating unit and its nonphosphorylated analogue, with a linker for conjugation, via a (4 + 2) convergent approach from a common AB(D)C tetrasaccharide intermediate.

摘要

艰难梭菌是医院获得性腹泻最常见的诊断原因，在老年和住院患者中的发病率和死亡率不断上升。我们首次通过（4 + 2）收敛方法，从常见的 AB(D)C 四糖中间体，合成了表面多糖 PS-II 重复单元及其非磷酸化类似物，并带有连接子用于缀合。