Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht,University of Utrecht, Utrecht, The Netherlands.
Eur Neuropsychopharmacol. 2011 Mar;21(3):274-81. doi: 10.1016/j.euroneuro.2010.11.006. Epub 2010 Dec 28.
Hyperactivity in anorexia nervosa (AN) is associated with low plasma leptin levels and negatively impacts on disease outcome. Using an animal model that mimics features of AN including food-restriction induced hyperlocomotion, we demonstrate that central leptin injections in the lateral ventricle and local injections of leptin into the ventral tegmental area (VTA) suppress running wheel activity. The results support that falling levels of leptin, that accompany caloric restriction, result in increased activity levels because of decreased leptin signaling in the VTA, part of the mesolimbic reward system.
神经性厌食症（AN）中的多动与血浆瘦素水平降低有关，并对疾病预后产生负面影响。我们使用一种模拟 AN 特征的动物模型，包括食物限制引起的过度活跃，证明了侧脑室中的中央瘦素注射和腹侧被盖区（VTA）中的瘦素局部注射可抑制跑步轮活动。这些结果支持这样的观点，即伴随热量限制的瘦素水平下降会导致活动水平增加，这是由于 VTA 中的瘦素信号减少，而 VTA 是中边缘奖励系统的一部分。
