神经性厌食症的内分泌并发症。
Endocrine complications of anorexia nervosa.
作者信息
Haines Melanie S
机构信息
Neuroendocrine Unit, Massachusetts General Hospital, 50 Staniford Street, Suite 750B, Boston, MA, 02114, USA.
Harvard Medical School, Boston, MA, USA.
出版信息
J Eat Disord. 2023 Feb 15;11(1):24. doi: 10.1186/s40337-023-00744-9.
Abstract
An important component in the treatment of anorexia nervosa (AN) is the evaluation and management of its endocrine complications, including functional hypogonadotropic hypogonadism and increased fracture risk. The body's adaptive response to chronic starvation results in many endocrine abnormalities, most of which are reversible upon weight restoration. A multidisciplinary team with experience in treating patients with AN is critical to improving endocrine outcomes in patients with this disorder, including in women with AN who are interested in fertility. Much less is understood about endocrine abnormalities in men, as well as sexual and gender minorities, with AN. In this article, we review the pathophysiology and evidence-based recommendations for the treatment of endocrine complications in AN, as well as discuss the status of clinical research in this area.
摘要
神经性厌食症（AN）治疗中的一个重要组成部分是对其内分泌并发症的评估和管理，包括功能性低促性腺激素性性腺功能减退和骨折风险增加。身体对慢性饥饿的适应性反应会导致许多内分泌异常，其中大多数在体重恢复后是可逆的。一个在治疗AN患者方面有经验的多学科团队对于改善这种疾病患者的内分泌结局至关重要，包括对生育感兴趣的AN女性患者。对于患有AN的男性以及性少数群体的内分泌异常了解得要少得多。在本文中，我们回顾了AN内分泌并发症治疗的病理生理学和循证建议，并讨论了该领域的临床研究现状。
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