Mutwalli Hiba, Keeler Johanna L, Chung Raymond, Dalton Bethan, Patsalos Olivia, Hodsoll John, Schmidt Ulrike, Breen Gerome, Treasure Janet, Himmerich Hubertus
Centre for Research in Eating and Weight Disorders (CREW), Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, UK.
Department of Clinical Nutrition, College of Applied Medical Sciences, Imam Abdulrahman Bin Faisal University, Dammam 34221, Saudi Arabia.
Nutrients. 2025 Apr 14;17(8):1341. doi: 10.3390/nu17081341.
: Recent research has established that metabolic factors may increase the vulnerability to develop anorexia nervosa (AN). The aim of this study was to explore the serum concentrations of leptin, insulin-like growth factor-1 (IGF-1), insulin and insulin receptor substrate (IRS-1) as possible state or trait biomarkers for AN in the acute and recovery (recAN) phases. Our secondary aim was to test associations between the tested markers and demographic and clinical characteristics. : This cross-sectional study included data from 56 participants with AN, 24 recAN participants and 51 healthy controls (HCs). Enzyme-linked immunosorbent assays (ELISAs) were used to quantify serum concentrations of leptin, IGF-1, insulin and IRS-1. An analysis of covariance (ANCOVA) and linear regression models were utilised to test our results. : There were significant differences with a large effect size between the groups for serum leptin ( < 0.001; = 0.80), whereby people with AN had lower leptin than those with recAN ( = 0.023; = 0.35) and HCs ( < 0.001; = 0.74). The between-group comparison of IGF-1 did not reach significance, although the effect size was moderate ( = 0.6) and was driven by lower levels of IGF-1 in people with acute AN compared to HCs ( = 0.036; = 0.53). Serum insulin and IRS-1 did not differ between groups. : Low leptin levels seen in individuals with AN may be due to starvation leading to fatty tissue depletion. Understanding the regulation of IGF-1 and insulin signalling over the course of the disorder requires further investigation.
近期研究已证实，代谢因素可能会增加患神经性厌食症（AN）的易感性。本研究旨在探讨瘦素、胰岛素样生长因子-1（IGF-1）、胰岛素和胰岛素受体底物（IRS-1）的血清浓度，将其作为AN在急性期和康复期（recAN）可能的状态或特质生物标志物。我们的次要目的是测试所检测标志物与人口统计学和临床特征之间的关联。 ：这项横断面研究纳入了56名AN患者、24名recAN参与者和51名健康对照者（HCs）的数据。采用酶联免疫吸附测定（ELISA）法对瘦素、IGF-1、胰岛素和IRS-1的血清浓度进行定量。运用协方差分析（ANCOVA）和线性回归模型来检验我们的结果。 ：血清瘦素水平在各组之间存在显著差异，效应量较大（<0.001；=0.80），AN患者的瘦素水平低于recAN患者（=0.023；=0.35）和HCs（<0.001；=0.74）。IGF-1的组间比较未达到显著水平，尽管效应量中等（=0.6），且是由急性AN患者的IGF-1水平低于HCs所驱动（=0.036；=0.53）。各组之间血清胰岛素和IRS-1无差异。 ：AN患者中观察到的低瘦素水平可能是由于饥饿导致脂肪组织消耗。了解IGF-1和胰岛素信号在该疾病过程中的调节机制需要进一步研究。
