诺德斯有什么新消息？

What is new with Nods?

机构信息

Department of Immunology, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8.

出版信息

Curr Opin Immunol. 2011 Feb;23(1):29-34. doi: 10.1016/j.coi.2010.12.003. Epub 2010 Dec 27.

DOI:10.1016/j.coi.2010.12.003

PMID:21190821

Abstract

Over the last few years, much research has focused on determining the function of members of the cytosolic Nod-like receptor (NLR) family in terms of their triggers and the signaling pathways that they control. Members of this family include the NLRP proteins, which play a role in sensing both microbial and danger signals and triggering the caspase-1 dependent inflammasome, and the Nod subfamily characterized by proteins with a caspase-activating and recruitment domain (CARD) or a so-called 'X' domain. Nod1, Nod2, NLRX1 and NLRC5 are all members of this subfamily and in this review, we will focus on recent work that has shown the importance of these molecules in both pathogen sensing and regulation of innate and adaptive immunity.

摘要

在过去的几年中，大量的研究集中于确定细胞质核苷酸结合寡聚结构域样受体（NLR）家族成员的功能，包括它们的触发物以及它们所控制的信号通路。该家族的成员包括 NLRP 蛋白，其在感知微生物和危险信号以及触发半胱天冬酶-1 依赖性炎性小体方面发挥作用，以及以具有半胱天冬酶激活和募集结构域（CARD）或所谓的“X”结构域的蛋白为特征的 Nod 亚家族。Nod1、Nod2、NLRX1 和 NLRC5 均属于该亚家族，在这篇综述中，我们将重点介绍最近的研究工作，这些研究工作表明这些分子在病原体感知和先天免疫及适应性免疫的调节中的重要性。