从 D-(-)-泛内酯合成杀软体动物剂氰醇内酯大环内酯。
Synthesis of molluscicidal agent cyanolide a macrolactone from D-(-)-pantolactone.
机构信息
Advinus Therapeutics Ltd., Pune, India.
出版信息
J Org Chem. 2011 Feb 4;76(3):963-6. doi: 10.1021/jo101782q. Epub 2010 Dec 31.
PMID:21192736
Abstract
An efficient synthesis of potent molluscicidal agent cyanolide A, a glycosidic 16-membered macrolide, starting from D-(-)-pantolactone is reported. Highly stereoselective aldol, oxa-Michael addition, and Yamaguchi macrolactonization are the key steps in the present synthesis.
摘要
本文报道了从 D-(-)-泛内酯出发高效合成具有强杀软体动物活性的糖苷类 16 元大环内酯化合物氰醇 A 的方法。立体选择性羟醛缩合、氧杂-Michael 加成和 Yamaguchi 大环内酯化是本合成方法的关键步骤。
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