Department of Anesthesiology, The Ottawa Hospital, 1053 Carling Avenue, Box 249C, Ottawa, ON K1Y 4E9, Canada.
Can J Anaesth. 2011 Mar;58(3):267-74. doi: 10.1007/s12630-010-9448-4. Epub 2010 Dec 31.
The Clock Drawing Test (CDT) is a screening tool for dementia that tests a variety of cognitive domains. The CDT takes a maximum of two minutes to complete and might be helpful in identifying postoperative cognitive disorders at the bedside. The objective of this study was to evaluate the accuracy of the CDT in a population at high risk for postoperative cognitive disorders
In this prospective observational cohort study, patients were recruited who were ≥ 60 yr of age and scheduled for elective open repair of the abdominal aorta. Delirium was assessed using the Confusion Assessment Method (CAM) on postoperative days (POD) 2 and 4 and at discharge. Cognitive function was assessed with neuropsychometric tests before surgery and at discharge. Postoperative cognitive dysfunction (POCD) was determined using the Reliable Change Index. Clock Drawing Tests were administered at all time points. Agreement between the CDT and test for delirium or POCD was assessed with Cohen's Kappa statistic.
Delirium was noted in 30 of 83 patients (36%; 95% confidence interval [CI] 26 to 46%) during their hospital stay, while POCD was noted in 48 of 78 patients (60%; 95% CI 51 to 72%) at discharge. Agreement between the CDT and CAM was poor at three intervals (Kappa 0.06 to 0.29), as was POCD at discharge (Kappa 0.46). Sensitivity of the CDT was <0.71 for both delirium and POCD at all intervals. False positives and negatives were common.
Agreement between CDT and tests for delirium and POCD was poor; sensitivity was inadequate for a screening test. (ClinicalTrials.gov number, NCT00911677).
画钟测验(CDT)是一种用于痴呆症的筛查工具,可测试多种认知领域。CDT 最多需要两分钟即可完成,并且可能有助于在床边识别术后认知障碍。本研究的目的是评估 CDT 在术后认知障碍高风险人群中的准确性。
在这项前瞻性观察队列研究中,招募了年龄≥60 岁且计划接受择期开放修复腹主动脉的患者。术后第 2 天和第 4 天以及出院时使用意识模糊评估方法(CAM)评估谵妄。手术前和出院时使用神经心理测试评估认知功能。使用可靠变化指数确定术后认知功能障碍(POCD)。在所有时间点均进行画钟测验。使用 Cohen 的 Kappa 统计评估 CDT 与谵妄或 POCD 测试之间的一致性。
在住院期间,30 例 83 例患者(36%;95%置信区间 [CI] 26 至 46%)出现谵妄,而 48 例 78 例患者(60%;95%CI 51 至 72%)在出院时出现 POCD。CDT 与 CAM 在三个时间间隔的一致性较差(Kappa 值为 0.06 至 0.29),而 POCD 在出院时的一致性也较差(Kappa 值为 0.46)。CDT 在所有时间间隔的谵妄和 POCD 的敏感性均<0.71。假阳性和假阴性很常见。
CDT 与谵妄和 POCD 测试之间的一致性较差;敏感性不足以作为筛查测试。(临床试验注册号,NCT00911677)。