Metastasis and Angiogenesis Research Group, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
Front Biosci (Landmark Ed). 2011 Jan 1;16(3):898-936. doi: 10.2741/3726.
Tight Junctions (TJ) are well known to function as a control for the paracellular diffusion of ions and certain molecules, it has however, become evident that the TJ has a vital role in maintaining cell to cell integrity. Loss of cohesion of the TJ structure can lead to invasion and ultimately to the metastasis of cancer cells. This review will discuss how modulation of expression of TJ molecules results in key changes in TJ barrier function leading to the progression of cancer and progression of metastasis.
紧密连接（TJ）是众所周知的离子和某些分子的细胞旁扩散的控制，然而，TJ 在维持细胞间完整性方面起着至关重要的作用。TJ 结构的凝聚力丧失可导致侵袭，并最终导致癌细胞转移。本文综述了 TJ 分子表达的调节如何导致 TJ 屏障功能的关键变化，从而导致癌症的进展和转移的进展。
