Department of Translational Medicine, The John Curtin School of Medical Research, The Australian National University, Garran Rd, building 131, Canberra, Australia.
Front Biosci (Landmark Ed). 2011 Jan 1;16(5):1634-50. doi: 10.2741/3810.
There is increasing evidence that obesity may have pathophysiological effects that extend beyond its well-known co-morbidities; in particular its role in cancer has received considerable epidemiological support. As adipose tissue becomes strongly established as an endocrine organ, two of its most abundant and most investigated adipokines, leptin and adiponectin, are also taken beyond their traditional roles in energy homeostasis, and are implicated as mediators of the effects of obesity on cancer development. This review examines these adipokines in relation to the prostate, breast, colorectal, thyroid, renal, pancreatic, endometrial and oesophageal cancers, and how they may orchestrate the influence of obesity on the development of these malignancies.
越来越多的证据表明，肥胖可能具有超出其众所周知的合并症的病理生理影响；特别是其在癌症中的作用已经得到了相当多的流行病学支持。随着脂肪组织被强烈认定为内分泌器官，它的两种最丰富和研究最多的脂肪因子——瘦素和脂联素——也超越了它们在能量平衡中的传统作用，并被认为是肥胖对癌症发展影响的介质。本文综述了这些脂肪因子与前列腺癌、乳腺癌、结直肠癌、甲状腺癌、肾癌、胰腺癌、子宫内膜癌和食管癌的关系，以及它们如何协调肥胖对这些恶性肿瘤发展的影响。
