Istituto Nazionale per la Ricerca sul Cancro, 16132 Genova, Italy.
Front Biosci (Landmark Ed). 2011 Jan 1;16(5):1787-96. doi: 10.2741/3821.
KSRP is a single-strand nucleic acids binding protein that affects RNA fate at multiple levels. KSRP modular structure and its complex pattern of post-translational modifications underpin the interaction with a wide spectrum of RNA target sequences, as well as with other RNA-binding proteins and molecular adaptors. These interactions are important to the regulation of different steps of mRNA metabolism and, in turn, modulate several aspects of cellular proliferation and differentiation. In this review we will discuss in detail KSRP ability to i) promote decay of labile mRNAs interacting with some components of the mRNA decay machinery and ii) favor the maturation of a select group of microRNA precursors.
KSRP 是一种单链核酸结合蛋白，可在多个层面影响 RNA 的命运。KSRP 的模块化结构及其复杂的翻译后修饰模式为其与广泛的 RNA 靶序列以及其他 RNA 结合蛋白和分子衔接蛋白相互作用奠定了基础。这些相互作用对于调节 mRNA 代谢的不同步骤非常重要，并进而调节细胞增殖和分化的几个方面。在这篇综述中，我们将详细讨论 KSRP 能够：i）促进与 mRNA 降解机制某些成分相互作用的不稳定 mRNA 的降解；ii）促进一组特定的 microRNA 前体的成熟。
