Gherzi Roberto, Chen Ching-Yi, Ramos Andres, Briata Paola
Gene Expression Regulation Laboratory, IRCCS Azienda Ospedaliera Universitaria San Martino-IST, 16132 Genova, Italy.
Department of Biochemistry & Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL, USA.
Semin Cell Dev Biol. 2014 Oct;34:2-8. doi: 10.1016/j.semcdb.2014.05.004. Epub 2014 May 17.
The single-strand-RNA binding protein KSRP is able to negatively regulate gene expression operating with at least two distinct and integrated postranscriptional mechanisms: (i) by promoting decay of unstable mRNAs and (ii) by favoring maturation from precursors of select microRNAs (miRNAs) including the prototypical tumor suppressor let-7. Studies performed in primary and cultured cells as well as in mice proved that the ability of KSRP to integrate different levels of gene expression is required for proper immune response, lipid metabolism, cell-fate decisions, tissue regeneration, and DNA damage response.
单链RNA结合蛋白KSRP能够通过至少两种不同且相互整合的转录后机制对基因表达进行负调控：（i）促进不稳定mRNA的降解；（ii）促进包括典型肿瘤抑制因子let-7在内的特定微小RNA（miRNA）前体的成熟。在原代细胞、培养细胞以及小鼠中进行的研究证明，KSRP整合不同水平基因表达的能力对于正常的免疫反应、脂质代谢、细胞命运决定、组织再生和DNA损伤反应是必需的。
