Beierle Elizabeth A
University of Alabama, Birmingham, Birmingham, AL 35233, USA.
Front Biosci (Elite Ed). 2011 Jan 1;3(2):421-33. doi: 10.2741/e257.
Neuroblastoma is the most common extracranial solid tumor of childhood. This tumor is characterized by poor survival, especially when it features amplification of the MYCN oncogene. The ability for human cancers to propagate is marked by their ability to invade and metastasize to distant sites. Focal adhesion kinase (FAK) is a key tyrosine kinase involved in the survival and metastasis of a number of human tumor types. We have shown that FAK is present in human neuroblastoma and that its expression in neuroblastoma is related to the MYCN oncogene. We have also demonstrated that inhibition of FAK in neuroblastoma leads to decreased tumor cell survival. The current review addresses the relationship between the MYCN oncogene, focal adhesion kinase and neuroblastoma.
神经母细胞瘤是儿童最常见的颅外实体瘤。这种肿瘤的特点是生存率低，尤其是当它具有MYCN癌基因扩增特征时。人类癌症的增殖能力以其侵袭和转移到远处部位的能力为标志。粘着斑激酶（FAK）是一种关键的酪氨酸激酶，参与多种人类肿瘤类型的生存和转移。我们已经表明FAK存在于人类神经母细胞瘤中，并且其在神经母细胞瘤中的表达与MYCN癌基因有关。我们还证明，抑制神经母细胞瘤中的FAK会导致肿瘤细胞存活率降低。本综述探讨了MYCN癌基因、粘着斑激酶与神经母细胞瘤之间的关系。
