Molla Maria Dolores Julia, Hidalgo-Mora Juan Jose, Soteras Marta Gurrea
Obstetrics and Gynecology Department. La Fe University Hospital, Valencia, Spain.
Front Biosci (Schol Ed). 2011 Jan 1;3(1):191-204. doi: 10.2741/s144.
Phytoestrogens are a group of non-steroidal compounds of plant origin that present structural and functional similarities with estradiol. Isoflavones are their most widely known category. There are different mechanisms of action of isoflavones accepted, although they may be considered as selective modulators of estrogen receptors. On the other hand, Cimicifuga Racemosa is a perennial plant used traditionally for problems related to menstruation. Its action mechanisms have not been totally identified. There is a growing interest in the usefulness of phytotherapy in the treatment of symptoms and menopause-related diseases. Isoflavones and Cimicifuga Racemosa moderately improve vasomotor symptoms in menopausal women, particularly in those who have a greater number of hot flushes. Furthermore, trials performed with soy isoflavones have observed a reduction of the loss of bone mineral density in postmenopausal women and a slight decrease in LDL cholesterol. In short, phytotherapy will constitute a therapeutic option that can offer assistance to women who want to improve their quality of life through relief of vasomotor symptoms or benefit from other effects for their health.
植物雌激素是一类源自植物的非甾体化合物,其在结构和功能上与雌二醇相似。异黄酮是其中最为人熟知的类别。尽管异黄酮可被视为雌激素受体的选择性调节剂,但目前公认其作用机制存在多种。另一方面,黑升麻是一种多年生植物,传统上用于治疗与月经相关的问题。其作用机制尚未完全明确。植物疗法在治疗更年期症状及相关疾病方面的效用正受到越来越多的关注。异黄酮和黑升麻可适度改善绝经后女性的血管舒缩症状,尤其是潮热次数较多的女性。此外,对大豆异黄酮进行的试验观察到,绝经后女性的骨矿物质密度流失有所减少,低密度脂蛋白胆固醇略有下降。简而言之,植物疗法将成为一种治疗选择,可为那些希望通过缓解血管舒缩症状来改善生活质量或从其他健康益处中获益的女性提供帮助。