异黄酮与女性健康。
Isoflavones and women's health.
作者信息
Powles Trevor
机构信息
Parkside Hospital, Wimbledon, London.
出版信息
Breast Cancer Res. 2004;6(3):140-2. doi: 10.1186/bcr796. Epub 2004 Apr 6.
Abstract
There is evidence that diets which contain high levels of phytoestrogenic isoflavanoids are associated with a low incidence of osteoporosis and menopausal vasomotor symptoms. Plant extracts such as red clover, which contain high levels of isoflavanoids, have been used to reduce menopausal symptoms and have been shown to reduce bone loss in healthy women. A placebo-controlled clinical trial [ISRCTN42940165] of red clover is reported in this issue of Breast Cancer Research and shows that these phytoestrogens do not cause any oestrogenic increase in breast density, which would indicate that they are unlikely to cause an increased risk of breast cancer.
摘要
有证据表明，含有高水平植物雌激素异黄酮的饮食与骨质疏松症和更年期血管舒缩症状的低发病率相关。诸如红三叶草之类含有高水平异黄酮的植物提取物已被用于减轻更年期症状，并已证明可减少健康女性的骨质流失。本期《乳腺癌研究》报道了一项红三叶草的安慰剂对照临床试验[ISRCTN42940165]，结果显示这些植物雌激素不会导致乳房密度出现任何雌激素性增加，这表明它们不太可能增加患乳腺癌的风险。
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2
The effects of phytoestrogen isoflavones on bone density in women: a double-blind, randomized, placebo-controlled trial.植物雌激素异黄酮对女性骨密度的影响：一项双盲、随机、安慰剂对照试验。
Am J Clin Nutr. 2004 Feb;79(2):326-33. doi: 10.1093/ajcn/79.2.326.
3
Mammographic densities in a one-year isoflavone intervention.为期一年的异黄酮干预中的乳腺钼靶密度
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Maturitas. 2002 Jul 25;42(3):187-93. doi: 10.1016/s0378-5122(02)00080-4.
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