Hu Shaowen, Cucinotta Francis A
Universities Space Research Association, Division of Space Life Sciences, Houston, TX 77058, USA.
Radiat Prot Dosimetry. 2011 Feb;143(2-4):196-201. doi: 10.1093/rpd/ncq519. Epub 2010 Dec 31.
Ku plays a crucial role in the non-homologous end joining pathway to repair DNA double-strand breaks. In this study, we modelled the full-length Ku heterodimer from the truncated crystal structure and NMR structure, and conducted a series of docking and molecular dynamics simulations in an effort to probe the structural, dynamical and energetic features of each domain in free Ku and Ku-DNA complexes.
Ku在修复DNA双链断裂的非同源末端连接途径中起着关键作用。在本研究中，我们根据截短的晶体结构和核磁共振结构对全长Ku异二聚体进行建模，并进行了一系列对接和分子动力学模拟，以探究游离Ku和Ku-DNA复合物中每个结构域的结构、动力学和能量特征。
