多形性腺瘤和癌在多形性腺瘤中的免疫组化表达 pRb。
Immunohistochemical expression of pRb in pleomorphic adenoma and carcinoma ex pleomorphic adenoma.
机构信息
Faculty of Dentistry, Aleppo University, Aleppo, Syria.
出版信息
Med Oral Patol Oral Cir Bucal. 2011 May 1;16(3):e323-9. doi: 10.4317/medoral.16.e323.
OBJECTIVE
This study aimed to characterize alteration in the immunohistochemical expression of pRb in normal tissue of the salivary gland surrounding pleomorphic adenoma, the tumor cells of pleomorphic adenomas, and carcinoma arising in pleomorphic adenoma.
STUDY DESIGN
A selected series of 29 cases of pleomorphic adenomas, and 27 cases of carcinoma ex-pleomorphic adenoma (undifferentiated and adenocarcinoma types) were examined.
RESULTS
The results showed that pRb expression was negative in the components of normal tissue of the salivary gland surrounding pleomorphic adenoma. PRb expression in pleomorphic adenomas shows that 2 cases out of 29 (6.9%) strongly expressed in the duct cells, 7/29 (24.1%) cases showed moderate staining. pRb nuclear staining in myxochondroid was identified in 10/29 (34.5%) cases of pleomorphic adenomas with weak staining, 6/29 (20.7%) with moderate staining. pRb was strongly expressed in carcinoma cells in 19 out of 27 cases (70.4%).
CONCLUSION
This study suggests the alteration of pRb expression would increase from pleomorphic adenoma to carcinoma arising in pleomorphic adenomas (6.9% versus 70.4%).
目的
本研究旨在描述在多形性腺瘤周围唾液腺正常组织、多形性腺瘤肿瘤细胞和多形性腺瘤衍生癌中，pRb 的免疫组织化学表达的改变。
研究设计
选择了 29 例多形性腺瘤和 27 例多形性腺瘤衍生癌（未分化型和腺癌型）病例进行研究。
结果
结果表明，多形性腺瘤周围唾液腺正常组织成分中 pRb 表达阴性。29 例多形性腺瘤中，2 例（6.9%）导管细胞强表达 PRb，7/29（24.1%）例中度染色。10/29（34.5%）例多形性腺瘤黏液软骨样区 pRb 核染色弱阳性，6/29（20.7%）例中度染色。27 例多形性腺瘤衍生癌中有 19 例（70.4%）癌细胞中 pRb 强表达。
结论
本研究提示 pRb 表达的改变从多形性腺瘤到多形性腺瘤衍生癌逐渐增加（6.9%对 70.4%）。
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