Malgaonkar Nikhil I, Abuderman Abdulwahab, Kharma M Y, Al-Maweri S A, Alaizari N A, Altamimi Ma, Darwish S, Tarakji Bassel
Faculty, Department of Oral Medicine and Diagnostic Sciences, Al Farabi Colleges , Riyadh, Saudi Arabia .
Faculty, Department of Basic Medical Sciences, College of Medicine, Prince Stam Bin Abdulaziz university .
J Clin Diagn Res. 2016 Jul;10(7):ZC01-4. doi: 10.7860/JCDR/2016/16719.8071. Epub 2016 Jul 1.
Salivary gland neoplasms are not uncommon lesions that are seen in the head and neck region. The role of cell cycle regulators as well as that of oncogenes remains unexplored in the pathogenesis of these neoplasms.
Present study was conducted to evaluate the expression of p27 in the three common salivary gland neoplasms.
A total of 34 cases (19 pleomorphic adenoma, 8 mucoepidermoid carcinoma and 7 adenoid cystic carcinoma) were included. The sections were subjected to p27 staining and rated for the expression.
Of the total 52.6% of pleomorphic adenoma cases, 25% of mucoepidermoid carcinoma cases and only 14.2% of adenoid cystic carcinoma cases showed strong expression suggesting variable p27 expression in both malignant neoplasms. Normal salivary gland tissue was stained as a positive control for the evaluation.
The results of the study suggest an important role for p27 in pathogenesis of mucoepidermoid carcinoma as well as adenoid cystic carcinoma while its role in pathogenesis of pleomorphic adenoma remains questionable keeping in view the strong expression of p27 in the same.
涎腺肿瘤是头颈部区域常见的病变。细胞周期调节因子以及癌基因在这些肿瘤发病机制中的作用尚未得到探索。
本研究旨在评估p27在三种常见涎腺肿瘤中的表达情况。
共纳入34例病例（19例多形性腺瘤、8例黏液表皮样癌和7例腺样囊性癌）。对切片进行p27染色并对表达情况进行评分。
在所有病例中，52.6%的多形性腺瘤病例、25%的黏液表皮样癌病例以及仅14.2%的腺样囊性癌病例显示强表达，提示这两种恶性肿瘤中p27表达存在差异。正常涎腺组织染色作为评估的阳性对照。
研究结果表明p27在黏液表皮样癌以及腺样囊性癌的发病机制中起重要作用，而鉴于其在多形性腺瘤中的强表达，其在多形性腺瘤发病机制中的作用仍存在疑问。
