Witte Thomas H, Cheetham Jonathan, Rawlinson Jeremy J, Soderholm L Vince, Ducharme Norm G
Equine Performance Testing Clinic, Department of Veterinary Clinical Sciences, Cornell University Hospital for Animals, Cornell University College of Veterinary Medicine, Ithaca, New York 14850, USA.
Can J Vet Res. 2010 Oct;74(4):299-304.
The objective of this study was to validate, both in vitro and in an ex vivo model, a technique for the measurement of forces exerted on surgical sutures. For this purpose, a stainless steel E-type buckle force transducer was designed and constructed. A strain gauge was mounted on the central beam of the transducer to measure transducer deformation. The transducer was tested and calibrated on a single strand of surgical suture during cyclic loading. Further validation was performed using a previously published cadaveric model of laryngoplasty in the horse. Linear regression of transducer output with actual force during calibration tests resulted in mean R² values of 1.00, 0.99, and 0.99 for rising slope, falling slope, and overall slope, respectively. The R² was not less than 0.96 across an average of 75 cycles per test. The difference between rising slope and falling slope was 4%. Over 45 846 samples, the predicted force from transducer output showed a mean error of 4%. In vitro validation produced an adjusted R² of 0.99 when the force on the suture was regressed against translaryngeal pressure in a mixed-effects model. E-type buckle force transducers showed a highly linear output over a physiological force range when applied to surgical suture in vitro and in an ex vivo model of laryngoplasty. With appropriate calibration and short-term in vivo implantation, these transducers may advance our knowledge of the mechanisms of success and failure of techniques, such as laryngoplasty, that use structural suture implants.
本研究的目的是在体外和离体模型中验证一种测量手术缝线所受作用力的技术。为此，设计并制作了一个不锈钢E型扣式力传感器。在传感器的中心梁上安装了一个应变片，用于测量传感器的变形。在循环加载过程中，对单根手术缝线进行了传感器测试和校准。使用先前发表的马喉成形术尸体模型进行了进一步验证。在校准测试中，传感器输出与实际力的线性回归结果显示，上升斜率、下降斜率和总体斜率的平均R²值分别为1.00、0.99和0.99。每次测试平均75个周期内，R²均不小于0.96。上升斜率与下降斜率之间的差异为4%。在超过45846个样本中，传感器输出预测力的平均误差为4%。在体外验证中，当在混合效应模型中将缝线上的力与经喉压力进行回归分析时，调整后的R²为0.99。当应用于体外喉成形术模型和手术缝线时，E型扣式力传感器在生理力范围内显示出高度线性输出。通过适当的校准和短期体内植入，这些传感器可能会增进我们对使用结构性缝线植入物的技术（如喉成形术）成败机制的了解。
