对葡萄牙1型艾滋病病毒患者的pol/env配对序列进行分子流行病学分析。
Molecular epidemiological analysis of paired pol/env sequences from Portuguese HIV type 1 patients.
作者信息
Abecasis Ana B, Martins Andreia, Costa Inês, Carvalho Ana P, Diogo Isabel, Gomes Perpétua, Camacho Ricardo J
机构信息
Centro de Malária e Outras Doenças Tropicais, Instituto de Higiene e Medicina Tropical, Lisbon, Portugal.
出版信息
AIDS Res Hum Retroviruses. 2011 Jul;27(7):803-5. doi: 10.1089/AID.2010.0312. Epub 2011 Feb 16.
The advent of new therapeutic approaches targeting env and the search for efficient anti-HIV-1 vaccines make it necessary to identify the number of recombinant forms using genomic regions that were previously not frequently sequenced. In this study, we have subtyped paired pol and env sequences from HIV-1 strains infecting 152 patients being clinically followed in Portugal. The percentage of strains in which we found discordant subtypes in pol and env was 25.7%. When the subtype in pol and env was concordant (65.1%), the most prevalent subtypes were subtype B (40.8%), followed by subtype C (17.8%) and subtype G (5.3%). The most prevalent recombinant form was CRF14_BGpol/Genv (7.2%).
针对env的新治疗方法的出现以及对高效抗HIV-1疫苗的探索，使得有必要利用以前测序不频繁的基因组区域来确定重组形式的数量。在本研究中，我们对来自感染葡萄牙152名临床随访患者的HIV-1毒株的pol和env序列对进行了亚型分析。我们发现pol和env中存在不一致亚型的毒株百分比为25.7%。当pol和env中的亚型一致时（65.1%），最常见的亚型是B亚型（40.8%），其次是C亚型（17.8%）和G亚型（5.3%）。最常见的重组形式是CRF14_BGpol/Genv（7.2%）。
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