Walsh Maeve L, Smith Victoria H, King Clodagh M
Department of Dermatology, Broadgreen Hospital, Liverpool, UK.
Australas J Dermatol. 2010 Nov;51(4):285-6. doi: 10.1111/j.1440-0960.2010.00664.x.
We report a case of type 1 and type IV contact hypersensitivity to nickel. Very few cases of immediate contact urticaria to nickel have been reported. The mechanism behind this is not fully understood, although it has been postulated that nickel may act as a mast cell discharger on a non-immunological basis. Nickel is found in varying concentrations in stainless steels; its biological availability varies depending on the alloy composition. Our patient has adapted her lifestyle to minimize her contact with household appliances containing nickel. If medical or dental treatment using stainless steel equipment is required, we recommend a short course of oral corticosteroids and antihistamines.
我们报告一例对镍的I型和IV型接触性超敏反应。既往报道的对镍的速发型接触性荨麻疹病例极少。尽管据推测镍可能在非免疫基础上作为肥大细胞促排剂，但其中的机制尚未完全明确。不锈钢中镍的含量各不相同；其生物利用度因合金成分而异。我们的患者已调整生活方式，尽量减少与含镍家用电器的接触。如果需要使用不锈钢设备进行医疗或牙科治疗，我们建议短期口服皮质类固醇和抗组胺药。
