Division of Nephrology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
Clin Transplant. 2012 Jan-Feb;26(1):74-81. doi: 10.1111/j.1399-0012.2010.01390.x. Epub 2010 Dec 27.
Higher education level might result in reduced disparities in access to renal transplantation. We analyzed two outcomes: (i) being placed on the waiting list or transplanted without listing and (ii) transplantation in patients who were placed on the waiting list. We identified 3224 adult patients with end-stage renal disease (ESRD) in United States Renal Data System with education information available (mean age of ESRD onset of 57.1 ± 16.2 yr old, 54.3% men, 64.2% white, and 50.4% diabetics). Compared to whites, fewer African Americans graduated from college (10% vs. 16.7%) and a higher percentage never graduated from the high school (38.6% vs. 30.8%). African American race was associated with reduced access to transplantation (hazard ratio [HR] 0.70, p < 0.001 for wait-listing/transplantation without listing; HR 0.58, p < 0.001 for transplantation after listing). African American patients were less likely to be wait-listed/transplanted in the three less-educated groups: HR 0.67 (p = 0.005) for those never completed high school, HR 0.76 (p = 0.02) for high school graduates, and HR 0.65 (p = 0.003) for those with partial college education. However, the difference lost statistical significance in those who completed college education (HR 0.75, p = 0.1). In conclusion, in comparing white and African American candidates, racial disparities in access to kidney transplantation do exist. However, they might be alleviated in highly educated individuals.
较高的教育水平可能会减少在获得肾移植方面的差距。我们分析了两个结果:(i)被列入等待名单或未列入等待名单而进行移植,以及(ii)列入等待名单的患者进行移植。我们在美国肾脏数据系统中确定了 3224 名具有教育信息的成年终末期肾病(ESRD)患者(ESRD 发病时的平均年龄为 57.1 ± 16.2 岁,男性占 54.3%,白人占 64.2%,糖尿病患者占 50.4%)。与白人相比,接受大学教育的非裔美国人较少(10%比 16.7%),而未从高中毕业的比例更高(38.6%比 30.8%)。非裔美国人的种族与获得移植的机会减少有关(等待名单/未列入等待名单的移植的风险比 [HR]为 0.70,p < 0.001;列入名单后的移植 HR 为 0.58,p < 0.001)。在三个受教育程度较低的群体中,非裔美国患者更不可能被列入等待名单/进行移植:未完成高中学业的 HR 为 0.67(p = 0.005),高中毕业生的 HR 为 0.76(p = 0.02),具有部分大学教育的 HR 为 0.65(p = 0.003)。但是,在完成大学教育的人群中,这种差异失去了统计学意义(HR 为 0.75,p = 0.1)。总之,在比较白人和非裔美国候选人时,确实存在获得肾移植机会的种族差异。但是,在受过高等教育的人群中,这些差异可能会得到缓解。