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教育对肾脏移植机会种族差异的影响。

Effect of education on racial disparities in access to kidney transplantation.

机构信息

Division of Nephrology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.

出版信息

Clin Transplant. 2012 Jan-Feb;26(1):74-81. doi: 10.1111/j.1399-0012.2010.01390.x. Epub 2010 Dec 27.

Abstract

Higher education level might result in reduced disparities in access to renal transplantation. We analyzed two outcomes: (i) being placed on the waiting list or transplanted without listing and (ii) transplantation in patients who were placed on the waiting list. We identified 3224 adult patients with end-stage renal disease (ESRD) in United States Renal Data System with education information available (mean age of ESRD onset of 57.1 ± 16.2 yr old, 54.3% men, 64.2% white, and 50.4% diabetics). Compared to whites, fewer African Americans graduated from college (10% vs. 16.7%) and a higher percentage never graduated from the high school (38.6% vs. 30.8%). African American race was associated with reduced access to transplantation (hazard ratio [HR] 0.70, p < 0.001 for wait-listing/transplantation without listing; HR 0.58, p < 0.001 for transplantation after listing). African American patients were less likely to be wait-listed/transplanted in the three less-educated groups: HR 0.67 (p = 0.005) for those never completed high school, HR 0.76 (p = 0.02) for high school graduates, and HR 0.65 (p = 0.003) for those with partial college education. However, the difference lost statistical significance in those who completed college education (HR 0.75, p = 0.1). In conclusion, in comparing white and African American candidates, racial disparities in access to kidney transplantation do exist. However, they might be alleviated in highly educated individuals.

摘要

较高的教育水平可能会减少在获得肾移植方面的差距。我们分析了两个结果:(i)被列入等待名单或未列入等待名单而进行移植,以及(ii)列入等待名单的患者进行移植。我们在美国肾脏数据系统中确定了 3224 名具有教育信息的成年终末期肾病(ESRD)患者(ESRD 发病时的平均年龄为 57.1 ± 16.2 岁,男性占 54.3%,白人占 64.2%,糖尿病患者占 50.4%)。与白人相比,接受大学教育的非裔美国人较少(10%比 16.7%),而未从高中毕业的比例更高(38.6%比 30.8%)。非裔美国人的种族与获得移植的机会减少有关(等待名单/未列入等待名单的移植的风险比 [HR]为 0.70,p < 0.001;列入名单后的移植 HR 为 0.58,p < 0.001)。在三个受教育程度较低的群体中,非裔美国患者更不可能被列入等待名单/进行移植:未完成高中学业的 HR 为 0.67(p = 0.005),高中毕业生的 HR 为 0.76(p = 0.02),具有部分大学教育的 HR 为 0.65(p = 0.003)。但是,在完成大学教育的人群中,这种差异失去了统计学意义(HR 为 0.75,p = 0.1)。总之,在比较白人和非裔美国候选人时,确实存在获得肾移植机会的种族差异。但是,在受过高等教育的人群中,这些差异可能会得到缓解。

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