Jaimovich D G, Rose W W
Department of Pediatrics, Michigan State University School of Medicine, Kalamazoo.
Crit Care Med. 1990 Oct;18(10):1164-6. doi: 10.1097/00003246-199010000-00022.
For the critically ill patient with complex and prolonged needs, multiple drug infusions and, when indicated, peripheral hyperalimentation require simultaneous administration through a simple peripheral catheter site with a multilumen catheter. We studied a double-lumen peripheral venous catheter. Ten domestic swine, 10 to 20 kg, were divided into two groups of five each. Total parenteral nutrition was administered through the distal port and phenytoin was administered as a bolus and as an infusion in each group. Samples were taken from two sites during the bolus and at 1, 5, and 15 min during phenytoin infusion. Electromagnetic flowmeter measurements were obtained for validation of flow. In all instances, our study showed that either the particle size was too small or the concentration of particles was less than 3 X 10(3)/microL: too small to be recovered in the study samples.
对于有复杂且长期需求的重症患者，多种药物输注以及在必要时进行的外周高营养支持需要通过带有多腔导管的简单外周导管部位同时给药。我们研究了一种双腔外周静脉导管。10头体重10至20千克的家猪被分成两组，每组5头。每组通过远端端口给予全胃肠外营养，并给予苯妥英推注和输注。在推注期间以及苯妥英输注期间的第1、5和15分钟从两个部位采集样本。通过电磁流量计测量以验证流量。在所有情况下，我们的研究表明，要么颗粒尺寸太小，要么颗粒浓度小于3×10³/微升：太小以至于在研究样本中无法回收。
