Center of Gastroenterology and Hepatology, Saiseikai Suita Hospital, Osaka, Japan.
J Gastroenterol Hepatol. 2011 Jan;26 Suppl 1:153-62. doi: 10.1111/j.1440-1746.2010.06547.x.
During the past 20 to 30 years, the frequency of patients presenting with nonalcoholic fatty liver diseases (NAFLD) has increased gradually in Japan in proportion to the increase in the population with life-style related diseases. We describe here the current status of the clinical and basic aspects of research into NAFLD in Japan. The increase in the incidence of life-style-related diseases has resulted in an increase in NAFLD throughout the past 20 to 30 years. The rate of obesity in the population is not high compared to western countries but the incidence of NAFLD is similar to those countries. In 2008 we started a nationwide study of NAFLD which has been supported by the Ministry of Labor and Welfare Japan. In this project, we planned to investigate the epidemiology, genetic backgrounds and biochemical markers, and liver injury in patients with diabetes mellitus (DM) and hepatocellular carcinoma in NASH, and treatment of NASH. Approximately 20 to 25% of DM patients showed NAFLD in which the prevalence of NASH might be more than 30 to 40%. Fortunately, we have been able to obtain very interesting results from our group studies, including single necleotide polymorphisms (SNPs) which will be published in the near future.
在过去的 20 到 30 年中，随着生活方式相关疾病患者人数的增加，日本非酒精性脂肪性肝病（NAFLD）患者的频率也逐渐增加。我们在这里描述日本 NAFLD 的临床和基础研究的现状。在过去的 20 到 30 年中，生活方式相关疾病的发病率增加导致了 NAFLD 的增加。与西方国家相比，日本的人口肥胖率并不高，但 NAFLD 的发病率与之相似。2008 年，我们开始了一项由日本劳动和福利部支持的全国性 NAFLD 研究。在这个项目中，我们计划调查糖尿病（DM）患者和 NASH 中肝细胞癌的流行病学、遗传背景和生化标志物以及肝损伤，以及 NASH 的治疗。大约 20%到 25%的 DM 患者患有 NAFLD，其中 NASH 的患病率可能超过 30%到 40%。幸运的是，我们能够从我们的小组研究中获得非常有趣的结果，包括即将发表的单核苷酸多态性（SNP）。
