Moradi Fateme, Moosavian Seyedeh Parisa, Djafari Farhang, Teimori Azam, Imani Zahra Faghih, Naeini Amirmansour Alavi
Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Community Nutrition, Vice-Chancellery for Health, Shiraz University of Medical Sciences, Shiraz, Iran.
J Diabetes Metab Disord. 2022 Mar 19;21(1):657-667. doi: 10.1007/s40200-022-01028-w. eCollection 2022 Jun.
Non-alcoholic fatty liver disease (NAFLD) is caused by the increase of fat in the liver. The present study aimed to study the association between different dietary patterns and NAFLD in adults.
This study included 121 adult patients with NAFLD and 119 non-NAFLD. Dietary intake was calculated by a 168-item food frequency questionnaire. Biochemical markers were measured. Dietary patterns were determined by factor analysis. The association between dietary patterns and NAFLD was evaluated using multiple logistic regression analysis.
Two dietary patterns (healthy, western) were recognized in participants. Western dietary pattern was related with 72 percent increase in the odds of NAFLD (OR: 1.72; 95% CI: 1.32,2.14), after adjustment for covariates. Healthy dietary pattern was associated with 38 percent lower odds of NAFLD (OR: 0.38; 95% CI: 0.11, 0.65). Adherence to the western diet was related to 0.486 greater amounts of ALT, 3.248 mg/dl higher levels of FBS, and 3.989 mg/dl greater amounts of TG and 2.354 mg/dl greater amounts of MDA after adjusting for confounding factors ( > 0.001, = 0.042, > 0.001, = 0.036 respectively). The healthy dietary pattern score was negatively associated with FBS and Cholesterol and TG levels ( = 0.035, = 0.048, and = 0.025), respectively. Moreover, it was associated with 3.211 mg/dl higher levels of TAC ( = 0.049).
There is a significant relationship between dietary patterns and non-alcoholic fatty liver disease. Adherence to a western dietary pattern is related to an increase in non-alcoholic fatty liver disease.
非酒精性脂肪性肝病（NAFLD）是由肝脏脂肪增加引起的。本研究旨在探讨成人不同饮食模式与NAFLD之间的关联。
本研究纳入了121例成年NAFLD患者和119例非NAFLD患者。通过168项食物频率问卷计算饮食摄入量。检测生化指标。通过因子分析确定饮食模式。使用多元逻辑回归分析评估饮食模式与NAFLD之间的关联。
参与者中识别出两种饮食模式（健康饮食模式、西方饮食模式）。调整协变量后，西方饮食模式与NAFLD患病几率增加72%相关（比值比：1.72；95%置信区间：1.32，2.14）。健康饮食模式与NAFLD患病几率降低38%相关（比值比：0.38；95%置信区间：0.11，0.65）。调整混杂因素后，坚持西方饮食与丙氨酸氨基转移酶（ALT）升高0.486、空腹血糖（FBS）水平升高3.248mg/dl、甘油三酯（TG）升高3.989mg/dl和丙二醛（MDA）升高2.354mg/dl相关（分别为P>0.001、P=0.042、P>0.001、P= 0.036）。健康饮食模式得分与FBS、胆固醇和TG水平呈负相关（分别为P=0.035、P=0.048和P=0.025）。此外，它与总抗氧化能力（TAC）水平升高3.211mg/dl相关（P=0.049）。
饮食模式与非酒精性脂肪性肝病之间存在显著关系。坚持西方饮食模式与非酒精性脂肪性肝病的增加有关。
