Wang Y L, Tang Z Z, Hu N, Wang X Q
Shanxi Cancer Institute, Taiyuan.
Chin Med J (Engl). 1990 Jul;103(7):565-71.
Chromosomal fragile sites analyses were performed in peripheral lymphocytes of 37 patients with lymphoma and 16 patients with leukemia, and also of 50 healthy individuals as controls. The results were: 1) The rates of chromosomal aberration and frequency of expression of fragile sites in patients with lymphoma and leukemia were significantly higher than those of normal controls. 2) There was a statistical association between 21 of 44 fragile sites and specific cancer breakpoints in patients with lymphoma and this was also the case with 19 of 30 fragile sites and specific cancer breakpoints in patients with leukemia. 3) Concordance between fragile sites and location of oncogenes in the diseases was established. The possible important role of fragile sites in the pathogenesis of lymphoma and leukemia is discussed.
对37例淋巴瘤患者、16例白血病患者的外周淋巴细胞以及50名健康个体作为对照进行了染色体脆性位点分析。结果如下：1）淋巴瘤和白血病患者的染色体畸变率和脆性位点表达频率显著高于正常对照组。2）44个脆性位点中的21个与淋巴瘤患者的特定癌症断点之间存在统计学关联，白血病患者的30个脆性位点中的19个与特定癌症断点之间也存在这种情况。3）确定了疾病中脆性位点与癌基因位置之间的一致性。讨论了脆性位点在淋巴瘤和白血病发病机制中可能的重要作用。
