Murata M
Gan No Rinsho. 1987 Apr;33(5 Suppl):581-6.
Chromosome instability is considered to be a probable candidate for a genetic predisposition to cancer. In order to confirm association of heritable fragile sites with cancer, an epidemiologic survey study was conducted which compared their incidence between patients of leukemia and allied diseases, and healthy subjects. The total incidence was 3.2% and 6.0% in patients and controls, which seemed to indicate that the carrier state of a fragile site is not a risk factor for cancer development. However the cases detected in the study were individually quite interesting: One was a coincident case of fra (16) (q22) and inversion of chromosome 16, and another was a coincidence of homozygous fra (17) (p12) and familial clustering of cancers. Chromosome instability, including the fragile sites, should be paid further attentions with respect to its role in the etiology of cancer.
染色体不稳定被认为是癌症遗传易感性的一个可能候选因素。为了证实遗传性脆性位点与癌症的关联，开展了一项流行病学调查研究，比较了白血病及相关疾病患者与健康受试者中脆性位点的发生率。患者组和对照组的总发生率分别为3.2%和6.0%，这似乎表明脆性位点的携带状态并非癌症发生的危险因素。然而，该研究中检测到的病例个体情况相当有趣：一例是fra(16)(q22)与16号染色体倒位的巧合病例，另一例是纯合子fra(17)(p12)与癌症家族聚集的巧合。包括脆性位点在内的染色体不稳定在癌症病因学中的作用应得到进一步关注。
