College of Staten Island, Program in evelopmental Neuroscience, The Graduate Center, City University of New York (CUNY), Staten Island, New York, USA.
Prog Mol Biol Transl Sci. 2011;98:47-83. doi: 10.1016/B978-0-12-385506-0.00002-8.
Alzheimer's disease is a progressive neurodegenerative disease that is characterized histopathologically by the presence of plaques, mainly composed of Abeta amyloid and the tangles, mainly composed of hyperphosphorylated tau. To date, there is no treatment that can reverse the disease, and all the current therapeutics is directed to cope with the symptoms of the disease. Here we describe the efforts dedicated to attack the plaques and, in more detail, the process of neurofibrillary degeneration, linked to the presence of the hyperphosphorylated microtubule associated protein tau. We have identified the different putative targets for therapeutics and the current knowledge on them.
阿尔茨海默病是一种进行性神经退行性疾病，其组织病理学特征是存在斑块，主要由 Abeta 淀粉样蛋白组成，以及缠结，主要由过度磷酸化的 tau 组成。迄今为止，尚无能够逆转该疾病的治疗方法，目前所有的治疗方法都旨在应对该疾病的症状。在这里，我们描述了针对斑块的治疗方法，更详细地描述了与过度磷酸化的微管相关蛋白 tau 存在相关的神经纤维变性过程。我们已经确定了不同的潜在治疗靶点及其目前的知识。
