Thanki K H, Schmidt C L
Department of Obstetrics and Gynecology, University of Medicine and Dentistry of New Jersey (UMDNJ), New Jersey Medical School, Newark 07103.
Fertil Steril. 1990 Oct;54(4):656-60. doi: 10.1016/s0015-0282(16)53825-4.
Follicular development and oocyte maturation were compared in 22 patients stimulated with human menopausal gonadotropins/human chorionic gonadotropin (hCG, group I) and in 52 women also treated with the gonadotropin-releasing hormone agonist (GnRH-a) leuprolide acetate (LA, group II). Suppression of endogenous leutinizing hormone (LH) surges by LA allowed delayed hCG administration, resulting in higher peripheral estradiol levels, more retrieved oocyte cumulus corona complexes, and greater numbers of cryopreserved embryos. Reduction in spontaneous LH surges in the GnRH-a cycles may have allowed time for larger follicular fluid (FF) volume accumulation during all phases of oocyte cumulus corona complex maturation, restoring synchrony between FF volume and oocyte cumulus corona complex maturity.
对22例接受人绝经期促性腺激素/人绒毛膜促性腺激素（hCG，第一组）刺激的患者以及52例还接受促性腺激素释放激素激动剂（GnRH-a）醋酸亮丙瑞林（LA，第二组）治疗的女性的卵泡发育和卵母细胞成熟情况进行了比较。LA对内源性促黄体生成素（LH）峰的抑制作用使得hCG给药得以延迟，从而导致外周雌二醇水平升高、回收的卵母细胞-卵丘-冠复合物数量增加以及冷冻保存胚胎数量增多。GnRH-a周期中自发性LH峰的减少可能为卵母细胞-卵丘-冠复合物成熟的各个阶段积累更大体积的卵泡液（FF）留出了时间，恢复了FF体积与卵母细胞-卵丘-冠复合物成熟度之间的同步性。
