Hofmann G E, Scott R T, Brzyski R G, Jones H W
Jones Institute for Reproductive Medicine, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk.
Fertil Steril. 1990 Aug;54(2):303-7.
Immunoreactive epidermal growth factor (EGF) was measured in follicular fluid (FF) obtained at the time of oocyte retrieval for in vitro fertilization from cycles with (91 follicles) and without (128 follicles) the gonadotropin-releasing hormone agonist leuprolide acetate (LA). Follicular fluid immunoreactive EGF levels in the non-LA cycles correlated with androstenedione but not estradiol or progesterone levels from follicles with prophase I oocytes or from all follicles taken together, but not from metaphase I or metaphase II oocyte containing follicles alone. In non-LA cycles, FF immunoreactive EGF levels were lower in follicles that contained metaphase I or II oocytes than prophase I oocytes. Additionally, FF immunoreactive EGF levels were lower in follicles containing metaphase I or II oocytes from non-LA than LA cycles. We conclude that immunoreactive EGF is present in FF. Leuprolide acetate may affect FF immunoreactive EGF levels.
在体外受精的卵母细胞采集时，从应用促性腺激素释放激素类似物醋酸亮丙瑞林（LA）的周期（91个卵泡）和未应用（128个卵泡）该药物的周期中获取卵泡液（FF），检测其中的免疫反应性表皮生长因子（EGF）。在非LA周期中，卵泡液免疫反应性EGF水平与有减数分裂前期I期卵母细胞的卵泡或所有卵泡的雄烯二酮相关，但与雌二醇或孕酮水平无关，单独与含有中期I期或中期II期卵母细胞的卵泡无关。在非LA周期中，含有中期I期或II期卵母细胞的卵泡中FF免疫反应性EGF水平低于含有减数分裂前期I期卵母细胞的卵泡。此外，非LA周期中含有中期I期或II期卵母细胞的卵泡中FF免疫反应性EGF水平低于LA周期。我们得出结论，FF中存在免疫反应性EGF。醋酸亮丙瑞林可能影响FF免疫反应性EGF水平。
