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1-苄基-3-(2-呋喃甲基)-1,2,3,4,5,6-六氢-螺[苯并[h]喹唑啉-5,1'-环己烷]-2,4-二酮

1-Benzyl-3-(2-furylmeth-yl)-1,2,3,4,5,6-hexa-hydro-spiro-[benzo[h]quinazoline-5,1'-cyclo-hexa-ne]-2,4-dione.

作者信息

Tamazyan Rafael, Ayvazyan Armen, Markosyan Ashot, Gabrielyan Siranush

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2008 Mar 29;64(Pt 4):o748. doi: 10.1107/S1600536808007502.

DOI:10.1107/S1600536808007502
PMID:21202138
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2961069/
Abstract

The title compound, C(29)H(28)N(2)O(3), displays anti-depressant and anti-cancer activities. The furan ring is disordered over two orientations [site occupancies 0.690 (12)/0.310 (12)] related by a rotation of 180°. The ring conformations are chair for the cyclo-hexane ring, boat for the cyclo-hexa-diene ring and twist for the pyrimidine ring. The crystal packing is determined solely by van der Waals inter-actions.

摘要

标题化合物C(29)H(28)N(2)O(3)具有抗抑郁和抗癌活性。呋喃环在通过180°旋转相关的两个取向[位点占有率0.690 (12)/0.310 (12)]上无序。环己烷环的环构象为椅式，环己二烯环为船式，嘧啶环为扭曲式。晶体堆积仅由范德华相互作用决定。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0fb/2961069/c4b547fb2ccf/e-64-0o748-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0fb/2961069/b31ceff6fc74/e-64-0o748-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0fb/2961069/7449eab6c60a/e-64-0o748-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0fb/2961069/c4b547fb2ccf/e-64-0o748-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0fb/2961069/b31ceff6fc74/e-64-0o748-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0fb/2961069/7449eab6c60a/e-64-0o748-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0fb/2961069/c4b547fb2ccf/e-64-0o748-fig3.jpg

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本文引用的文献

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