超氧化物参与凝血酶原谷氨酸残基维生素K依赖性羧化作用的证据。
Evidence for the involvement of superoxide in vitamin K-dependent carboxylation of glutamic acid residues of prothrombin.
作者信息
Esnouf M P, Green M R, Hill H A, Irvine G B, Walter S J
出版信息
Biochem J. 1978 Jul 15;174(1):345-8. doi: 10.1042/bj1740345.
Abstract
The formation of vitamin K epoxide and the vitamin K-dependent carboxylation of glutamic acid residues present in synthetic substrates and decarboxyprothrombin are both inhibited by superoxide dismutase. Catalase only inhibits the generation of vitamin K epoxide, suggesting that the carboxylation and epoxidation reactions are not inter-dependent.
摘要
超氧化物歧化酶可抑制维生素K环氧化物的形成以及合成底物和脱羧凝血酶原中谷氨酸残基的维生素K依赖性羧化作用。过氧化氢酶仅抑制维生素K环氧化物的生成，这表明羧化反应和环氧化反应并非相互依赖。
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Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein).超氧化物歧化酶。红细胞铜蛋白（血铜蛋白）的酶功能。
J Biol Chem. 1969 Nov 25;244(22):6049-55.
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Effect of superoxide generation and dismutation on hydroxylation reactions catalyzed by liver microsomal cytochrome P-450.超氧化物生成与歧化对肝微粒体细胞色素P-450催化的羟化反应的影响。
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