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[(2-羟基苯基)(吡啶-2-基氨基)甲基]膦酸乙酯甲醇溶剂合物

Ethyl [(2-hydroxy-phen-yl)(pyridinium-2-ylamino)meth-yl]phospho-nate methanol solvate.

作者信息

Li Ming-Xia, Zhu Miao-Li, Lu Li-Ping

机构信息

Institute of Molecular Science, Key Laboratory of Chemical Biology and Molecular Engineering of the Education Ministry, Shanxi University, Taiyuan, Shanxi 030006, People's Republic of China.

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2008 Jun 7;64(Pt 7):o1178-9. doi: 10.1107/S1600536808015675.

DOI:10.1107/S1600536808015675
PMID:21202822
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2961726/
Abstract

In the title compound, C(14)H(17)N(2)O(4)P·CH(3)OH, the planes of the pyridinium-2-ylamino and 2-hydroxy-phenyl groups form a dihedral angle of 75.6 (1)°, with the pyridinium NH group and the 2-hydroxy-phenyl OH group pointing in opposite directions. Three intra-molecular hydrogen bonds are observed. Two phospho-nate and two methanol mol-ecules are connected by O-H⋯O hydrogen bonds as a centrosymmetric dimeric cluster, and inter-act further with other dimeric clusters via N-H⋯O, O-H⋯O and C-H⋯O hydrogen bonds and C-H⋯π inter-actions, resulting in a sheet structure.

摘要

在标题化合物C(14)H(17)N(2)O(4)P·CH(3)OH中，吡啶-2-基氨基和2-羟基苯基的平面形成75.6 (1)°的二面角，吡啶鎓NH基团和2-羟基苯基OH基团指向相反方向。观察到三个分子内氢键。两个膦酸酯和两个甲醇分子通过O-H⋯O氢键连接成一个中心对称的二聚体簇，并通过N-H⋯O、O-H⋯O和C-H⋯O氢键以及C-H⋯π相互作用与其他二聚体簇进一步相互作用，形成层状结构。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c735/2961726/0de96337cfd0/e-64-o1178-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c735/2961726/dfc09c9c31c3/e-64-o1178-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c735/2961726/0de96337cfd0/e-64-o1178-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c735/2961726/dfc09c9c31c3/e-64-o1178-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c735/2961726/0de96337cfd0/e-64-o1178-fig2.jpg

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本文引用的文献

1
A short history of SHELX.SHELX简史。
Acta Crystallogr A. 2008 Jan;64(Pt 1):112-22. doi: 10.1107/S0108767307043930. Epub 2007 Dec 21.
2
Hydrogen-bonded networks in trans-3-(3-pyridyl)acrylic acid and rctt-3,3'-(3,4-dicarboxycyclobutane-1,2-diyl)dipyridinium dichloride.
Acta Crystallogr C. 2007 Aug;63(Pt 8):o441-4. doi: 10.1107/S0108270107027497. Epub 2007 Jul 5.
3
Synthesis of beta-aminophosphonates and -phosphinates.β-氨基膦酸酯和膦酸酯的合成。
Chem Rev. 2005 Mar;105(3):899-931. doi: 10.1021/cr040672y.
4
Aminophosphonic acids of potential medical importance.具有潜在医学重要性的氨基膦酸。
Curr Med Chem Anticancer Agents. 2001 Nov;1(3):301-12. doi: 10.2174/1568011013354543.
5
Aminophosphonate inhibitors of dialkylglycine decarboxylase: structural basis for slow binding inhibition.二烷基甘氨酸脱羧酶的氨基膦酸酯抑制剂：慢结合抑制的结构基础。
Biochemistry. 2002 Oct 15;41(41):12320-8. doi: 10.1021/bi026318g.