• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
5-Fluorouracil-based chemotherapy for colorectal cancer and MTHFR/MTRR genotypes.基于5-氟尿嘧啶的结直肠癌化疗与亚甲基四氢叶酸还原酶/甲硫氨酸合成酶还原酶基因分型
Br J Clin Pharmacol. 2011 Jul;72(1):162-3. doi: 10.1111/j.1365-2125.2010.03892.x.
2
MTHFR and MTRR genotype and haplotype analysis and colorectal cancer susceptibility in a case-control study from the Czech Republic.MTHFR 和 MTRR 基因型及单体型分析与捷克的病例对照研究中的结直肠癌易感性
Mutat Res. 2011 Mar 18;721(1):74-80. doi: 10.1016/j.mrgentox.2010.12.008. Epub 2011 Jan 4.
3
Methylenetetrahydrofolate reductase gene polymorphisms: genomic predictors of clinical response to fluoropyrimidine-based chemotherapy?亚甲基四氢叶酸还原酶基因多态性：基于氟嘧啶化疗临床反应的基因组预测指标？
Cancer Chemother Pharmacol. 2006 Jun;57(6):835-40. doi: 10.1007/s00280-005-0089-1. Epub 2005 Sep 27.
4
Methylenetetrahydrofolate reductase gene polymorphisms and response to fluorouracil-based treatment in advanced colorectal cancer patients.亚甲基四氢叶酸还原酶基因多态性与晚期结直肠癌患者对氟尿嘧啶类治疗的反应
Pharmacogenetics. 2004 Dec;14(12):785-92. doi: 10.1097/00008571-200412000-00001.
5
DPYD*2A and MTHFR C677T predict toxicity and efficacy, respectively, in patients on chemotherapy with 5-fluorouracil for colorectal cancer.DPYD*2A 和 MTHFR C677T 分别预测结直肠癌患者接受氟尿嘧啶化疗的毒性和疗效。
Cancer Chemother Pharmacol. 2018 Jan;81(1):119-129. doi: 10.1007/s00280-017-3478-3. Epub 2017 Nov 13.
6
MTHFR polymorphisms and 5-FU-based adjuvant chemotherapy in colorectal cancer.MTHFR基因多态性与结直肠癌中基于5-氟尿嘧啶的辅助化疗
Ann Oncol. 2009 Oct;20(10):1660-6. doi: 10.1093/annonc/mdp046. Epub 2009 May 22.
7
Methylenetetrahydrofolate reductase (MTHFR) variants and fluorouracil-based treatments in colorectal cancer.亚甲基四氢叶酸还原酶（MTHFR）变体与结直肠癌中基于氟尿嘧啶的治疗
Pharmacogenomics. 2007 Nov;8(11):1561-6. doi: 10.2217/14622416.8.11.1561.
8
Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and FOLFOX response in colorectal cancer patients.亚甲基四氢叶酸还原酶（MTHFR）基因多态性与结直肠癌患者 FOLFOX 反应的关系。
Br J Clin Pharmacol. 2010 Jan;69(1):58-66. doi: 10.1111/j.1365-2125.2009.03556.x.
9
MTHFR Glu429Ala and ERCC5 His46His polymorphisms are associated with prognosis in colorectal cancer patients: analysis of two independent cohorts from Newfoundland.亚甲基四氢叶酸还原酶 Glu429Ala 和 ERCC5 His46His 多态性与结直肠癌患者的预后相关：来自纽芬兰的两个独立队列的分析。
PLoS One. 2013 Apr 23;8(4):e61469. doi: 10.1371/journal.pone.0061469. Print 2013.
10
Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) gene polymorphisms as risk factors for hepatocellular carcinoma in a Korean population.亚甲基四氢叶酸还原酶（MTHFR）和蛋氨酸合成酶还原酶（MTRR）基因多态性作为韩国人群肝细胞癌的危险因素
Anticancer Res. 2008 Sep-Oct;28(5A):2807-11.

引用本文的文献

1
Hybrid Molecules with Purine and Pyrimidine Derivatives for Antitumor Therapy: News, Perspectives, and Future Directions.用于抗肿瘤治疗的含嘌呤和嘧啶衍生物的杂合分子：新进展、前景与未来方向
Molecules. 2025 Jun 23;30(13):2707. doi: 10.3390/molecules30132707.
2
Therapeutic efficacy of baicalein and 6-(methylsulfinyl)hexyl isothiocyanate, alone or in combination with 5-fluorouracil, in the treatment of colorectal cancer.黄芩素和6-(甲基亚磺酰基)己基异硫氰酸酯单独或与5-氟尿嘧啶联合用于治疗结直肠癌的疗效。
Naunyn Schmiedebergs Arch Pharmacol. 2025 Jun 10. doi: 10.1007/s00210-025-04274-w.
3
Regulatory role of non-coding RNAs in 5-Fluorouracil resistance in gastrointestinal cancers.非编码RNA在胃肠道癌对5-氟尿嘧啶耐药中的调控作用
Cancer Drug Resist. 2025 Jan 16;8:4. doi: 10.20517/cdr.2024.167. eCollection 2025.
4
Emerging therapeutic strategies for Wnt-dependent colon cancer targeting macropinocytosis.针对巨胞饮作用的Wnt依赖性结肠癌的新兴治疗策略
Cells Dev. 2024 Dec;180:203974. doi: 10.1016/j.cdev.2024.203974. Epub 2024 Nov 9.
5
Polo-like Kinase 1 Predicts Lymph Node Metastasis in Middle Eastern Colorectal Cancer Patients; Its Inhibition Reverses 5-Fu Resistance in Colorectal Cancer Cells.Polo-like Kinase 1 预测中东结直肠癌患者的淋巴结转移；其抑制作用可逆转结直肠癌细胞对 5-Fu 的耐药性。
Cells. 2024 Oct 14;13(20):1700. doi: 10.3390/cells13201700.
6
Decursin Induces G1 Cell Cycle Arrest and Apoptosis through Reactive Oxygen Species-Mediated Endoplasmic Reticulum Stress in Human Colorectal Cancer Cells in In Vitro and Xenograft Models.地榆苷通过活性氧介导的内质网应激诱导人结直肠癌细胞在体外和异种移植模型中的 G1 期细胞周期停滞和凋亡。
Int J Mol Sci. 2024 Sep 14;25(18):9939. doi: 10.3390/ijms25189939.
7
Targeted panel sequencing of pharmacogenes and oncodrivers in colorectal cancer patients reveals genes with prognostic significance.对结直肠癌患者的药物基因和致癌基因进行靶向 panel 测序，揭示了具有预后意义的基因。
Hum Genomics. 2024 Jul 19;18(1):83. doi: 10.1186/s40246-024-00644-2.
8
Programming tumor evolution with selection gene drives to proactively combat drug resistance.利用选择基因驱动对肿瘤进化进行编程，以主动对抗耐药性。
Nat Biotechnol. 2025 May;43(5):737-751. doi: 10.1038/s41587-024-02271-7. Epub 2024 Jul 4.
9
Economic evaluation of personalized vs. standard dosing of 5-fluorouracil in first-line chemotherapy for metastatic colorectal cancer in Australia.澳大利亚转移性结直肠癌一线化疗中5-氟尿嘧啶个性化给药与标准给药的经济学评估。
Br J Clin Pharmacol. 2025 Jun;91(6):1610-1618. doi: 10.1111/bcp.16013. Epub 2024 Feb 12.
10
Albendazole inhibits colon cancer progression and therapy resistance by targeting ubiquitin ligase RNF20.阿苯达唑通过靶向泛素连接酶 RNF20 抑制结肠癌的进展和治疗耐药性。
Br J Cancer. 2024 Apr;130(6):1046-1058. doi: 10.1038/s41416-023-02570-x. Epub 2024 Jan 26.

本文引用的文献

1
Pharmacogenetic assessment of toxicity and outcome in patients with metastatic colorectal cancer treated with LV5FU2, FOLFOX, and FOLFIRI: FFCD 2000-05.转移性结直肠癌患者接受 LV5FU2、FOLFOX 和 FOLFIRI 治疗的毒性和结局的药物遗传学评估：FFCD 2000-05。
J Clin Oncol. 2010 May 20;28(15):2556-64. doi: 10.1200/JCO.2009.25.2106. Epub 2010 Apr 12.
2
Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and FOLFOX response in colorectal cancer patients.亚甲基四氢叶酸还原酶（MTHFR）基因多态性与结直肠癌患者 FOLFOX 反应的关系。
Br J Clin Pharmacol. 2010 Jan;69(1):58-66. doi: 10.1111/j.1365-2125.2009.03556.x.
3
MTHFR polymorphisms and 5-FU-based adjuvant chemotherapy in colorectal cancer.MTHFR基因多态性与结直肠癌中基于5-氟尿嘧啶的辅助化疗
Ann Oncol. 2009 Oct;20(10):1660-6. doi: 10.1093/annonc/mdp046. Epub 2009 May 22.
4
Methylenetetrahydrofolate reductase (MTHFR) variants and fluorouracil-based treatments in colorectal cancer.亚甲基四氢叶酸还原酶（MTHFR）变体与结直肠癌中基于氟尿嘧啶的治疗
Pharmacogenomics. 2007 Nov;8(11):1561-6. doi: 10.2217/14622416.8.11.1561.
5
Cancer pharmacogenetics: polymorphisms, pathways and beyond.癌症药物遗传学：多态性、信号通路及其他
Nat Rev Cancer. 2003 Dec;3(12):912-20. doi: 10.1038/nrc1233.
6
Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms: relationships with 5-fluorouracil sensitivity.胸苷酸合成酶和亚甲基四氢叶酸还原酶基因多态性：与5-氟尿嘧啶敏感性的关系
Br J Cancer. 2004 Jan 26;90(2):526-34. doi: 10.1038/sj.bjc.6601523.
7
Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate.亚甲基四氢叶酸还原酶C677T基因多态性对结肠癌细胞和乳腺癌细胞对5-氟尿嘧啶及甲氨蝶呤化疗敏感性的影响
J Natl Cancer Inst. 2004 Jan 21;96(2):134-44. doi: 10.1093/jnci/djh015.
8
5-fluorouracil: mechanisms of action and clinical strategies.5-氟尿嘧啶：作用机制与临床策略
Nat Rev Cancer. 2003 May;3(5):330-8. doi: 10.1038/nrc1074.
9
Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer.亚叶酸钙与氟尿嘧啶联合或不联合奥沙利铂作为晚期结直肠癌的一线治疗方案。
J Clin Oncol. 2000 Aug;18(16):2938-47. doi: 10.1200/JCO.2000.18.16.2938.
10
Resistance to fluorodeoxyuridine-induced DNA damage and cytotoxicity correlates with an elevation of deoxyuridine triphosphatase activity and failure to accumulate deoxyuridine triphosphate.对氟脱氧尿苷诱导的DNA损伤和细胞毒性的抗性与脱氧尿苷三磷酸酶活性的升高以及脱氧尿苷三磷酸积累失败相关。
Cancer Res. 1993 Nov 1;53(21):5219-24.

5-Fluorouracil-based chemotherapy for colorectal cancer and MTHFR/MTRR genotypes.

作者信息

Pardini Barbara, Kumar Rajiv, Naccarati Alessio, Novotny Jan, Prasad Rashmi B, Forsti Asta, Hemminki Kari, Vodicka Pavel, Lorenzo Bermejo Justo

出版信息

Br J Clin Pharmacol. 2011 Jul;72(1):162-3. doi: 10.1111/j.1365-2125.2010.03892.x.

DOI:10.1111/j.1365-2125.2010.03892.x
PMID:21204909
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3141199/
Abstract
摘要