5-Fluorouracil-based chemotherapy for colorectal cancer and MTHFR/MTRR genotypes.
作者信息
Pardini Barbara, Kumar Rajiv, Naccarati Alessio, Novotny Jan, Prasad Rashmi B, Forsti Asta, Hemminki Kari, Vodicka Pavel, Lorenzo Bermejo Justo
出版信息
Br J Clin Pharmacol. 2011 Jul;72(1):162-3. doi: 10.1111/j.1365-2125.2010.03892.x.
Abstract
摘要
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Pharmacogenetic assessment of toxicity and outcome in patients with metastatic colorectal cancer treated with LV5FU2, FOLFOX, and FOLFIRI: FFCD 2000-05.转移性结直肠癌患者接受 LV5FU2、FOLFOX 和 FOLFIRI 治疗的毒性和结局的药物遗传学评估：FFCD 2000-05。
J Clin Oncol. 2010 May 20;28(15):2556-64. doi: 10.1200/JCO.2009.25.2106. Epub 2010 Apr 12.
2
Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and FOLFOX response in colorectal cancer patients.亚甲基四氢叶酸还原酶（MTHFR）基因多态性与结直肠癌患者 FOLFOX 反应的关系。
Br J Clin Pharmacol. 2010 Jan;69(1):58-66. doi: 10.1111/j.1365-2125.2009.03556.x.
3
MTHFR polymorphisms and 5-FU-based adjuvant chemotherapy in colorectal cancer.MTHFR基因多态性与结直肠癌中基于5-氟尿嘧啶的辅助化疗
Ann Oncol. 2009 Oct;20(10):1660-6. doi: 10.1093/annonc/mdp046. Epub 2009 May 22.
4
Methylenetetrahydrofolate reductase (MTHFR) variants and fluorouracil-based treatments in colorectal cancer.亚甲基四氢叶酸还原酶（MTHFR）变体与结直肠癌中基于氟尿嘧啶的治疗
Pharmacogenomics. 2007 Nov;8(11):1561-6. doi: 10.2217/14622416.8.11.1561.
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Cancer pharmacogenetics: polymorphisms, pathways and beyond.癌症药物遗传学：多态性、信号通路及其他
Nat Rev Cancer. 2003 Dec;3(12):912-20. doi: 10.1038/nrc1233.
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Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms: relationships with 5-fluorouracil sensitivity.胸苷酸合成酶和亚甲基四氢叶酸还原酶基因多态性：与5-氟尿嘧啶敏感性的关系
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Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate.亚甲基四氢叶酸还原酶C677T基因多态性对结肠癌细胞和乳腺癌细胞对5-氟尿嘧啶及甲氨蝶呤化疗敏感性的影响
J Natl Cancer Inst. 2004 Jan 21;96(2):134-44. doi: 10.1093/jnci/djh015.
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5-fluorouracil: mechanisms of action and clinical strategies.5-氟尿嘧啶：作用机制与临床策略
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Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer.亚叶酸钙与氟尿嘧啶联合或不联合奥沙利铂作为晚期结直肠癌的一线治疗方案。
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