Department of Plant Physiology, University of Rostock, 18051 Rostock, Germany.
Sci Signal. 2011 Jan 4;4(154):jc1. doi: 10.1126/scisignal.2001404.
The highly diffusible free radical nitric oxide (NO) has emerged as a key signaling molecule in bacteria, plants, and animals. There are several mechanisms through which NO is produced in plants, and once produced, NO readily reacts with various targets, such as thiols and the metallic centers of proteins. During the past few years, S-nitrosylation, the covalent and reversible binding of NO to the thiols of reduced reactive cysteine residues, has emerged as an important posttranslational modification. S-nitrosylation is thought to account for much of the widespread influence of NO on cellular signaling through redox-based biochemical regulation of signaling components. Here, I highlight the emerging roles of S-nitrosylation in plants with particular emphasis on the role of S-nitrosylation in mitochondria during the defense response.
具有高扩散性的自由基一氧化氮（NO）已成为细菌、植物和动物中关键的信号分子。植物中有几种产生 NO 的机制，一旦产生，NO 就会很容易与各种靶标（如硫醇和蛋白质的金属中心）发生反应。在过去的几年中，S-亚硝基化，即 NO 与还原型半胱氨酸残基的巯基共价且可逆地结合，已成为一种重要的翻译后修饰。S-亚硝基化被认为是 NO 通过基于氧化还原的信号成分的生化调节对细胞信号产生广泛影响的主要原因。在这里，我将重点介绍 S-亚硝基化在植物中的新作用，特别强调 S-亚硝基化在防御反应中在线粒体中的作用。
