甲基强的松龙与罗格列酮（一种过氧化物酶体增殖物激活受体γ）对脊髓损伤后的比较神经保护作用。

Comparative neuroprotective effects of methylprednisolone and rosiglitazone, a peroxisome proliferator-activated receptor-γ following spinal cord injury.

作者信息

Zhang Qin, Huang Chen, Tang Tiansi, Shi Qin, Yang Huilin

机构信息

Department of Orthopedics, First Affiliated Hospital of Soochow University, No. 188 Shizi Street, Suzhou 215006, China.

出版信息

Neurosciences (Riyadh). 2011 Jan;16(1):46-52.

PMID:21206444

Abstract

OBJECTIVE

To compare the neuroprotective effects of methylprednisolone (MPSS) and rosiglitazone (ROSG) following spinal cord injury (SCI).

METHODS

This study was carried out at the Institute of Orthopedics, the First Affiliated Hospital of Soochow University, Suzhou, China between June 2009 and March 2010. One hundred and twenty Sprague-Dawley rats after SCI were divided into 4 different groups (30/group): i) SCI-vehicle group, ii) MPSS group, iii) ROSG group, and iv) sham saline group. The following 5 aspects were evaluated: 1) spinal cord inflammation and tissue injury; 2) neutrophil infiltration; 3) cell apoptosis; 4) the expression of proinflammatory cytokines tumor necrosis factor-α and interleukin-β; and 5) the expression of tissue Bax, Bcl-2, and HSP70 proteins in situ.

RESULTS

Notably, ROSG showed similar neuroprotective effects to MPSS, and significantly decreased spinal cord damage, apoptosis, and cytokine expression. There were no significant differences between the MPSS or ROSG-treated groups.

CONCLUSION

Administration of ROSG after SCI reduces the development of inflammation and tissue injury associated with spinal cord trauma.

摘要

目的

比较甲基强的松龙（MPSS）和罗格列酮（ROSG）对脊髓损伤（SCI）后的神经保护作用。

方法

本研究于2009年6月至2010年3月在中国苏州大学附属第一医院骨科研究所进行。120只脊髓损伤后的Sprague-Dawley大鼠被分为4组（每组30只）：i）SCI-载体组，ii）MPSS组，iii）ROSG组，iv）假生理盐水组。评估以下5个方面：1）脊髓炎症和组织损伤；2）中性粒细胞浸润；3）细胞凋亡；4）促炎细胞因子肿瘤坏死因子-α和白细胞介素-β的表达；5）组织Bax、Bcl-2和HSP70蛋白的原位表达。