Department of Bromatology, Faculty of Pharmacy, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.
Int J Obes (Lond). 2011 Sep;35(9):1225-32. doi: 10.1038/ijo.2010.267. Epub 2011 Jan 4.
To examine the potential association between Chlamydophila pneumoniae infection and obesity indicators after controlling for nutrient and energy intake, as well as age, smoking status, physical activity and educational level.
A total of 118 healthy adult females randomly recruited from the local community of Bydgoszcz, aged 20-80 years.
Serum was tested for specific IgG antibodies against C. pneumoniae using qualitative enzyme linked immunosorbent assay. Usual dietary intake was assessed by a 7-day food record. Information regarding smoking, physical activity and educational level was collected using the questionnaire. Body mass index (BMI) and percentage of total body fat (%FM) were calculated respectively, as weight (kilograms) divided by height (meters) squared and with the equations of Durnin and Womersley.
The prevalence of C. pneumoniae infection was significantly higher among overweight/obese subjects (77.1 vs 60.0%; P=0.047) in comparison with normal-weight individuals. Using multivariate regression analysis, a significant positive association of BMI (β=0.194; P=0.036) and %FM (β=0.176; P=0.049) with C. pneumoniae IgG antibody positivity was found after adjustment for age, total energy intake, percentage of energy from fat, carbohydrate and protein, physical activity, educational level and smoking habits. Moreover, the multivariable adjusted odds ratio of being overweight/obese for the seropositive group compared with seronegative individuals was 1.70 (95% confidence interval: 1.02-2.89; P=0.037).
The results indicated that C. pneumoniae infection may be associated with a risk of becoming overweight/developing obesity independently of dietary and lifestyle factors.
在控制营养素和能量摄入以及年龄、吸烟状况、身体活动和教育水平等因素后，研究肺炎衣原体感染与肥胖指标之间的潜在关联。
从比得哥什当地社区随机招募的 118 名年龄在 20-80 岁之间的健康成年女性。
使用定性酶联免疫吸附试验检测血清中针对肺炎衣原体的特异性 IgG 抗体。通过 7 天的食物记录评估常规饮食摄入。使用问卷收集吸烟、身体活动和教育水平的信息。体重指数（BMI）和体脂肪百分比（%FM）分别计算为体重（千克）除以身高（米）的平方和 Durnin 和 Womersley 的方程。
与正常体重个体相比，超重/肥胖者（77.1%比 60.0%；P=0.047）中肺炎衣原体感染的患病率明显更高。使用多元回归分析，在校正年龄、总能量摄入、脂肪、碳水化合物和蛋白质能量百分比、身体活动、教育水平和吸烟习惯后，BMI（β=0.194；P=0.036）和%FM（β=0.176；P=0.049）与肺炎衣原体 IgG 抗体阳性呈显著正相关。此外，与血清阴性个体相比，血清阳性组超重/肥胖的多变量调整比值比为 1.70（95%置信区间：1.02-2.89；P=0.037）。
结果表明，肺炎衣原体感染可能与超重/肥胖的风险独立于饮食和生活方式因素相关。
