Fernández-Real José-Manuel, Ferri Maria-José, Vendrell Joan, Ricart Wifredo
Section of Diabetes, Endocrinology and Nutrition, Institut d'Investigació Biomédica de Girona, Avinguda de França s/n, 17007 Girona, Spain.
Obesity (Silver Spring). 2007 Jan;15(1):245-52. doi: 10.1038/oby.2007.541.
Our aim was to study the effect of exposure to four infections on fat mass.
This was a cross-sectional study of healthy middle-aged men from the general population (n = 74). Each study subject's serum was tested for specific IgG class antibodies against herpes simplex virus (HSV)-1, HSV-2, enteroviruses, and Chlamydia pneumoniae through the use of quantitative in vitro enzyme-linked immunosorbent assays (ELISAs). A total pathogen burden score based on these seropositivities [Quantitative Seropositivity Index (QSI)] was constructed. Fat mass was measured by bioelectrical impedance.
We observed significant relationships between the HSV-1 titer and fat mass and percentage fat mass. The associations were stronger when considering the infection burden. The QSI was significantly associated with fat mass (r = 0.30, p = 0.009) and percentage fat mass (r = 0.27, p = 0.01). Those subjects in the highest tertile of fat mass showed significantly higher QSI (259.5 +/- 74.1 vs. 206.9 +/- 78.2, p = 0.007). In subjects that were seropositive for Enteroviruses, the relationship between the QSI and fat mass was strengthened (r = 0.51, p = 0.02). In a multivariate regression analysis, the QSI, independently of age and C-reactive protein, contributed to 9% of fat mass variance.
Pathogen burden showed an association with fat mass. Subjects with increased fat mass could be more susceptible to developing multiple infections resulting in a chronic low-grade inflammation. We can not exclude the possibility that exposure to multiple infections leads to increased fat mass.
我们的目的是研究暴露于四种感染对脂肪量的影响。
这是一项针对普通人群中健康中年男性（n = 74）的横断面研究。通过使用定量体外酶联免疫吸附测定（ELISA），对每位研究对象的血清进行针对单纯疱疹病毒（HSV）-1、HSV-2、肠道病毒和肺炎衣原体的特异性IgG类抗体检测。基于这些血清阳性结果构建了一个总病原体负担评分[定量血清阳性指数（QSI）]。通过生物电阻抗测量脂肪量。
我们观察到HSV-1滴度与脂肪量及脂肪量百分比之间存在显著关系。在考虑感染负担时，这种关联更强。QSI与脂肪量（r = 0.30，p = 0.009）和脂肪量百分比（r = 0.27，p = 0.01）显著相关。脂肪量处于最高三分位数的那些受试者显示出显著更高的QSI（259.5±74.1对206.9±78.2，p = 0.007）。在肠道病毒血清阳性的受试者中，QSI与脂肪量之间的关系得到加强（r = 0.51，p = 0.02）。在多变量回归分析中，独立于年龄和C反应蛋白的QSI解释了9%的脂肪量变异。
病原体负担与脂肪量相关。脂肪量增加的受试者可能更容易发生多种感染，从而导致慢性低度炎症。我们不能排除暴露于多种感染导致脂肪量增加的可能性。
