钯介导的基因编码芳基卤代物的选择性铃木-宫浦蛋白质修饰。
Palladium-mediated site-selective Suzuki-Miyaura protein modification at genetically encoded aryl halides.
机构信息
Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK.
出版信息
Chem Commun (Camb). 2011 Feb 14;47(6):1698-700. doi: 10.1039/c0cc04970k. Epub 2011 Jan 4.
PMID:21206952
Abstract
Site-specific genetic incorporation of unnatural p-halophenylalanine amino acid residues as 'tags' coupled with Pd(0)-mediated Suzuki-Miyuara 'modification' has been enabled by discovery of an effective small molecule palladium scavenger.
摘要
通过发现一种有效的小分子钯清除剂，实现了将非天然对卤苯丙氨酸氨基酸残基作为“标签”进行特异性基因掺入，并与 Pd(0)介导的 Suzuki-Miyuara“修饰”相结合。
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