Marschollek M, Rehwald A, Wolf K H, Gietzelt M, Nemitz G, Meyer Zu Schwabedissen H, Haux R
Peter L. Reichertz Institute for Medical Informatics, University of Braunschweig-Institute of Technology and Hanover Medical School, 30625 Hanover, Germany.
Methods Inf Med. 2011;50(5):420-6. doi: 10.3414/ME10-01-0040. Epub 2011 Jan 5.
Falls are a predominant problem in our aging society, often leading to severe somatic and psychological consequences, and having an incidence of about 30% in the group of persons aged 65 years or above. In order to identify persons at risk, many assessment tools and tests have been developed, but most of these have to be conducted in a supervised setting and are dependent on an expert rater.
The overall aim of our research work is to develop an objective and unobtrusive method to determine individual fall risk based on the use of motion sensor data. The aims of our work for this paper are to derive a fall risk model based on sensor data that may potentially be measured during typical activities of daily life (aim #1), and to evaluate the resulting model with data from a one-year follow-up study (aim #2).
A sample of n = 119 geriatric inpatients wore an accelerometer on the waist during a Timed 'Up & Go' test and a 20 m walk. Fifty patients were included in a one-year follow-up study, assessing fall events and scoring average physical activity at home in telephone interviews. The sensor data were processed to extract gait and dynamic balance parameters, from which four fall risk models--two classification trees and two logistic regression models--were computed: models CT#1 and SL#1 using accelerometer data only, models CT#2 and SL#2 including the physical activity score. The risk models were evaluated in a ten-times tenfold cross-validation procedure, calculating sensitivity (SENS), specificity (SPEC), positive and negative predictive values (PPV, NPV), classification accuracy, area under the curve (AUC) and the Brier score.
Both classification trees show a fair to good performance (models CT#1/CT#2): SENS 74%/58%, SPEC 96%/82%, PPV 92%/ 74%, NPV 77%/82%, accuracy 80%/78%, AUC 0.83/0.87 and Brier scores 0.14/0.14. The logistic regression models (SL#1/SL#2) perform worse: SENS 42%/58%, SPEC 82%/ 78%, PPV 62%/65%, NPV 67%/72%, accuracy 65%/70%, AUC 0.65/0.72 and Brier scores 0.23/0.21.
Our results suggest that accelerometer data may be used to predict falls in an unsupervised setting. Furthermore, the parameters used for prediction are measurable with an unobtrusive sensor device during normal activities of daily living. These promising results have to be validated in a larger, long-term prospective trial.
在我们这个老龄化社会中,跌倒问题十分突出,常常会导致严重的躯体和心理后果,在65岁及以上人群中的发生率约为30%。为了识别有风险的人群,已经开发了许多评估工具和测试方法,但其中大多数都必须在有监督的环境中进行,并且依赖于专家评分者。
我们研究工作的总体目标是开发一种基于运动传感器数据来确定个体跌倒风险的客观且不引人注意的方法。本文的工作目标是基于可能在日常生活典型活动中测量到的传感器数据推导一个跌倒风险模型(目标#1),并用一项为期一年的随访研究数据评估所得模型(目标#2)。
119名老年住院患者的样本在定时起立行走测试和20米步行过程中在腰部佩戴加速度计。50名患者被纳入为期一年的随访研究,通过电话访谈评估跌倒事件并对在家中的平均身体活动进行评分。对传感器数据进行处理以提取步态和动态平衡参数,据此计算出四个跌倒风险模型——两棵分类树和两个逻辑回归模型:仅使用加速度计数据的模型CT#1和SL#1,包括身体活动评分的模型CT#2和SL#2。在十次十折交叉验证过程中对风险模型进行评估,计算灵敏度(SENS)、特异度(SPEC)、阳性和阴性预测值(PPV、NPV)、分类准确率、曲线下面积(AUC)和布里尔评分。
两棵分类树均表现出较好到良好的性能(模型CT#1/CT#2):灵敏度74%/58%,特异度96%/82%,阳性预测值92%/74%,阴性预测值77%/82%,准确率80%/78%,AUC 0.83/0.87,布里尔评分0.14/0.14。逻辑回归模型(SL#1/SL#2)表现较差:灵敏度42%/58%,特异度82%/78%,阳性预测值62%/65%,阴性预测值67%/72%,准确率65%/70%,AUC 0.65/0.72,布里尔评分0.23/0.21。
我们的结果表明,加速度计数据可用于在无监督环境中预测跌倒。此外,用于预测的参数可在日常生活正常活动期间通过不引人注意的传感器设备进行测量。这些有前景的结果必须在更大规模的长期前瞻性试验中得到验证。