Steffenhagen N, Rummel-Kluge C, Himmerich H
Klinik und Poliklinik für Psychiatrie, Medizinische Fakultät der Universität Leipzig, Semmelweisstr. 10, 04103, Leipzig, Deutschland.
Nervenarzt. 2012 Mar;83(3):337-44. doi: 10.1007/s00115-010-3207-1.
Patients with severe mental illness, such as schizophrenia, depression or bipolar disorder, are more likely to be overweight and to suffer from dyslipidaemia, diabetes or cardiovascular disease. Unhealthy lifestyles, including poor diet and sedentary behaviour, but also pharmacotherapy contribute to the adverse risk profile. This article reviews the epidemiology and pharmacodynamics of metabolic abnormalities in psychiatric patients treated with antipsychotics, focusing on substance-specific differences.
患有严重精神疾病（如精神分裂症、抑郁症或双相情感障碍）的患者更有可能超重，并患有血脂异常、糖尿病或心血管疾病。不健康的生活方式，包括不良饮食和久坐不动的行为，以及药物治疗，都会导致不良风险状况。本文综述了接受抗精神病药物治疗的精神病患者代谢异常的流行病学和药效学，重点关注药物特异性差异。
