Trottmann M, Köhn F M, Dickmann M, Stief C G, Becker A J
Urologische Klinik und Poliklinik, Ludwig-Maximilians-Universität München, Campus Großhadern, Klinikum der Universität München, Marchioninistraße 15, 81377 München, Deutschland.
Urologe A. 2011 Jan;50(1):8-16. doi: 10.1007/s00120-010-2437-y.
Medical treatment of oligoasthenoteratozoospermia (OAT) syndrome includes many different treatment concepts. The targeted causes in the treatment of OAT syndrome are either hormonal, as for example hypothalamic, pituary, or, seldom, hyperprolactinemic disturbances, or acute or chronic urogenital infections, as well as ejaculatory disorders. Often no pathogenic reason for OAT syndrome can be found and targeted. Most treatment concepts in the past tried to improve sperm quality. Administration of antiestrogens, antioxidants, hormones, and micronutrients has been tried and used to improve sperm quality. The present article provides an overview of current medical treatment options for OAT syndrome, including former unsuccessful treatment concepts. The article furthermore sketches out potential treatment options, which might be available in the future.
少弱畸精子症（OAT）综合征的医学治疗包括许多不同的治疗理念。OAT综合征治疗的目标病因要么是激素方面的，例如下丘脑、垂体，或者很少见的高催乳素血症紊乱，要么是急性或慢性泌尿生殖系统感染，以及射精障碍。通常找不到OAT综合征的致病原因并确定其靶点。过去大多数治疗理念都试图改善精子质量。曾尝试并使用抗雌激素、抗氧化剂、激素和微量营养素来改善精子质量。本文概述了OAT综合征目前的医学治疗选择，包括以前未成功的治疗理念。此外，本文还概述了未来可能可用的潜在治疗选择。
