Department of Cardiology, Ahi Evren Cardiovascular and Thoracic Surgery Training and Research Hospital, Trabzon, Turkey.
Clin Res Cardiol. 2011 Jun;100(6):511-4. doi: 10.1007/s00392-010-0274-z. Epub 2011 Jan 5.
Lipoprotein-associated phospholipase A2 (Lp-PLA2) is among the multiple cardiovascular biomarkers that have been associated with increased cardiovascular disease. Lp-PLA2 appears, however, to be relatively unique in its high specificity for vascular inflammation as opposed to systemic inflammation, its low biologic variability, and its direct role in the causal pathway of plaque inflammation. Nevertheless, the relation between LP-PLA2 and isolated coronary artery ectasia (CAE) has not been investigated yet. The aim of our study was to assess this relation.
Twenty-five patients with isolated CAE without stenosis and 25 control subjects with angiographically normal coronary arteries were included in this study. Lp-PLA2 mass was determined in serum by a dual monoclonal antibody immunoassay.
Patients with isolated CAE had significantly higher level of Lp-PLA2 compared to the control subjects with angiographically normal coronary arteries (284 ± 102 ng/ml in ectasia and 199 ± 62 ng/ml in control group, respectively, p 0.001). Also we detected a significant positive correlation between the presence of CAE and Lp-PLA2 (r = 0.452, p 0.001).
We have demonstrated for the first time increased Lp-PLA2 level in patients with isolated CAE, suggesting that Lp-PLA2 may be involved in the pathogenesis of CAE.
脂蛋白相关磷脂酶 A2（Lp-PLA2）是与心血管疾病风险增加相关的多种心血管生物标志物之一。然而，与全身性炎症相比，Lp-PLA2 对血管炎症具有较高的特异性、较低的生物学变异性以及在斑块炎症的因果途径中具有直接作用，这使其具有相对独特的地位。然而，脂蛋白相关磷脂酶 A2（Lp-PLA2）与孤立性冠状动脉扩张症（CAE）之间的关系尚未得到研究。本研究旨在评估这种关系。
本研究纳入了 25 例无狭窄的孤立性 CAE 患者和 25 例冠状动脉造影正常的对照组患者。采用双单克隆抗体免疫测定法测定血清中 Lp-PLA2 质量。
与冠状动脉造影正常的对照组患者相比，孤立性 CAE 患者的 Lp-PLA2 水平显著升高（分别为 284±102ng/ml 和 199±62ng/ml，p<0.001）。此外，我们还检测到 CAE 的存在与 Lp-PLA2 之间存在显著正相关（r=0.452，p<0.001）。
我们首次证明了孤立性 CAE 患者的 Lp-PLA2 水平升高，表明 Lp-PLA2 可能参与 CAE 的发病机制。
