从轴突-胶质细胞信号传递到髓鞘形成：少突胶质细胞 Fyn 激酶的整合作用。
From axon-glial signalling to myelination: the integrating role of oligodendroglial Fyn kinase.
机构信息
Molecular Cell Biology, Department of Biology, Johannes Gutenberg University of Mainz, Bentzelweg 3, Mainz, Germany.
出版信息
Cell Mol Life Sci. 2011 Jun;68(12):2003-12. doi: 10.1007/s00018-010-0616-z. Epub 2011 Jan 5.
Abstract
Central nervous system myelination requires recognition and signalling processes between neuronal axons and oligodendrocytes. Complex cellular rearrangements occur in myelination-competent oligodendrocytes requiring spatio-temporal control mechanisms. Although the molecular repertoire is becoming increasingly transparent, the signalling mechanisms governing myelination initiation are only poorly understood. The non-receptor tyrosine kinase Fyn has been implicated in axon-glial signal transduction and in several cellular processes required for oligodendrocyte maturation and myelination. Here, we review oligodendroglial Fyn signalling and discuss the role of Fyn in axon-glia interaction mediating myelination.
摘要
中枢神经系统髓鞘形成需要神经元轴突和少突胶质细胞之间的识别和信号转导过程。髓鞘形成能力的少突胶质细胞中会发生复杂的细胞重排，这需要时空控制机制。尽管分子谱正在变得越来越透明，但髓鞘形成起始的信号转导机制仍知之甚少。非受体酪氨酸激酶 Fyn 已被牵连到轴突-胶质细胞信号转导以及少突胶质细胞成熟和髓鞘形成所需的几种细胞过程中。在这里，我们回顾了少突胶质细胞 Fyn 信号，并讨论了 Fyn 在介导髓鞘形成的轴突-胶质相互作用中的作用。
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本文引用的文献
1
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Biochim Biophys Acta. 2010 Oct;1798(10):1854-63. doi: 10.1016/j.bbamem.2010.06.009. Epub 2010 Jun 18.
2
Elevated phosphatidylinositol 3,4,5-trisphosphate in glia triggers cell-autonomous membrane wrapping and myelination.胶质细胞中升高的磷脂酰肌醇 3,4,5-三磷酸触发细胞自主的膜包裹和髓鞘形成。
J Neurosci. 2010 Jun 30;30(26):8953-64. doi: 10.1523/JNEUROSCI.0219-10.2010.
3
Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation.跨膜受体 DCC 与蛋白质合成机制结合并调节翻译。
Cell. 2010 May 14;141(4):632-44. doi: 10.1016/j.cell.2010.04.008. Epub 2010 Apr 29.
4
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5
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6
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J Neurosci. 2009 Jul 22;29(29):9174-85. doi: 10.1523/JNEUROSCI.5942-08.2009.
8
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Mol Neurobiol. 2009 Aug;40(1):55-72. doi: 10.1007/s12035-009-8071-2. Epub 2009 May 19.
9
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10
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