Voigt M, Straube S, Gulashvili A, Schild R L, Hallier E, Briese V
Institute for Perinatal Auxology, Klinikum Südstadt, Südring 76, Rostock, Germany.
Z Geburtshilfe Neonatol. 2010 Dec;214(6):229-33. doi: 10.1055/s-0030-1255026. Epub 2011 Jan 4.
The aim of this study was to compare neonatal outcomes in primiparous women with and without previous extrauterine pregnancies.
We analysed data from 207 171 singleton pregnancies in primiparous women from the German Perinatal Survey of 1998-2000. To minimise confounding factors, we only included women without previous miscarriages or terminations of pregnancy and performed comparisons separately for 3 maternal age groups as well as for all cases together.
Women with and without previous extrauterine pregnancies were of comparable height and weight but women with previous extrauterine pregnancies were on average older (29.2 vs. 26.6 years). The preterm birth rate was higher in women with previous extrauterine pregnancies (9.4% vs. 6.8%, odds ratio 1.42 [95% confidence interval 1.18-1.69], p<0.001; analysing all cases together) as was the rate of neonates with a low birth weight ≤ 2 499 g (7.9% vs. 5.7%, odds ratio 1.43 [95% confidence interval 1.17-1.72], p>0.001; analysing all cases together). The proportions of neonates classified as small, appropriate, or large for gestational age were rather similar in women with and without previous extrauterine pregnancies; likewise Apgar scores differed only slightly, although for some comparisons statistical significance was reached in spite of the small magnitude of differences.
Previous extrauterine pregnancies are associated with higher rates of preterm birth and infants of low birth weight in subsequent pregnancies.
本研究旨在比较有和没有宫外妊娠史的初产妇的新生儿结局。
我们分析了1998 - 2000年德国围产期调查中207171例初产妇单胎妊娠的数据。为尽量减少混杂因素，我们仅纳入了无既往流产或终止妊娠史的女性，并分别对3个产妇年龄组以及所有病例进行了比较。
有和没有宫外妊娠史的女性身高和体重相当，但有宫外妊娠史的女性平均年龄更大（29.2岁对26.6岁）。有宫外妊娠史的女性早产率更高（9.4%对6.8%，比值比1.42 [95%置信区间1.18 - 1.69]，p<0.001；分析所有病例），出生体重≤2499g的低体重新生儿率也是如此（7.9%对5.7%，比值比1.43 [95%置信区间1.17 - 1.72]，p>0.001；分析所有病例）。在有和没有宫外妊娠史的女性中，根据胎龄分类为小样儿、适于胎龄儿或大于胎龄儿的新生儿比例相当相似；同样，阿氏评分仅有轻微差异，尽管对于某些比较，尽管差异幅度较小，但仍达到了统计学显著性。
既往宫外妊娠与随后妊娠中较高的早产率和低体重儿发生率相关。
